Lysosomes in normal pancreatic beta cells.

Diabetologia ·Vol. 14 ·No. 5 ·1978-05-00 ·Pages 305-10

Meda P

Abstract

Lysosomes and their relationships with surrounding organelles were studied in pancreatic B-cells of normal Wistar rats by electron microscopy and cytochemical localization of acid phosphatase (AcPase) and arylsulphatase. Several forms of lysosomes were distinguished and shown to interact frequently with the secretory granules. Two different digestive processes were recognized. During crinophagy, lysosomes directly fuse with secretory granules while, during autophagy, a cytoplasmic area containing secretory granules and/or other organelles is circumscribed before the enzymatic digestion. In addition, lysosomes may transport arylsulphatase into secretory granules apparently not involved in a destructive process. Such a process could also account, at least in part, for the presence of AcPase in a certain number of mature and immature secretory granules.

MeSH Terms

Acid Phosphatase/metabolism Animals Arylsulfatases/metabolism Islets of Langerhans/cytology Lysosomes/enzymology Male Rats

Chemicals

Acid Phosphatase Arylsulfatases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Meda P

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28 references, click to expand

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Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF01223021

Published

1978-05-00

Pages

305-10

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/BF01223021 View journal details

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