Home LiteratureArticle Details
PMID: 4602673 Published · ppublish English Journal Article Review

A portrait of the pancreatic B-cell. The Minkowski Award Lecture delivered on July 19, 1973, during the 8th Congress of the International Diabetes Federation, held in Brussels, Belgium.

Diabetologia ·Vol. 10 ·No. 3 ·1974-06-00 ·Pages 163-87

Orci L

Abstract

暂无摘要

MeSH Terms
Cell Nucleus Cytoplasm Desmosomes Endocytosis Endoplasmic Reticulum Exocytosis Extracellular Space Freeze Etching Golgi Apparatus/physiology Histocytochemistry Insulin/biosynthesis Intercellular Junctions Islets of Langerhans/cytology Membranes/physiology Microscopy, Electron Mitochondria Models, Biological Pancreas/cytology,metabolism Proinsulin/biosynthesis
Chemicals
Insulin Proinsulin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Orci L
References (53)
53 references, click to expand
  1. Hexagonal array of subunits in intercellular junctions of the mouse heart and liver.
    J Cell Biol. 1967 Jun;33(3):C7-C12 PMID: 6036535
  2. Ultrastructural studies of the hyperplastic islets of Langerhans of spiny mice (Acomys cahirinus) before and during the development of hyperglycemia.
    Diabetologia. 1967 Apr;3(2):188-211 PMID: 4907140
  3. A new freezing-ultramicrotome.
    J Biophys Biochem Cytol. 1961 May;10:1-13 PMID: 13772269
  4. Pancreatic beta-cell web: its possible role in insulin secretion.
    Science. 1972 Mar 10;175(4026):1128-30 PMID: 4551150
  5. Monolayer cell culture of neonatal rat pancreas: an ultrastructural and biochemical study of functioning endocrine cells.
    J Ultrastruct Res. 1973 May;43(3):270-97 PMID: 4351013
  6. Electron microscopy of the pancreatic islets of the rat. Effects of prolonged insulin injections.
    Diabetes. 1966 Nov;15(11):823-9 PMID: 5924616
  7. Insulin secretion: multifactorial regulation for a single process of release. The Minkowski award lecture delivered on September 7, 1972 before the European Association for the study of Diabetes at Madrid, Spain.
    Diabetologia. 1973 Jun;9(3):167-73 PMID: 4368828
  8. Variations in tight and gap junctions in mammalian tissues.
    J Cell Biol. 1972 Jun;53(3):758-76 PMID: 4337577
  9. Morphological and biochemical studies of B cells of fetal rat endocrine pancreas in organ culture. Evidence for (pro) insulin biosynthesis.
    J Cell Biol. 1971 Sep;50(3):565-82 PMID: 5098861
  10. Pronase effect on pancreatic beta cell secretion and morphology.
    Science. 1973 May 11;180(4086):647-9 PMID: 4573394
  11. FINE STRUCTURE IN FROZEN-ETCHED YEAST CELLS.
    J Cell Biol. 1963 Jun 1;17(3):609-28 PMID: 19866628
  12. Beta granule formation in isolated islets of langerhans: a study by electron microscopic radioautography.
    J Cell Biol. 1969 Sep;42(3):695-705 PMID: 4895597
  13. SECRETION OF PROTEIN BY THE ACINAR CELLS OF THE RAT PANCREAS AS STUDIED BY ELECTRON MICROSCOPIC RADIOAUTOGRAPHY.
    Anat Rec. 1964 Mar;148:485-97 PMID: 14153307
  14. Electron microscopic studies on the secretory mechanism of pancreatic islet cells, with particular reference to beta cells. I. Normal secretion in mice, rats, rabbits and chickens, and secretion stimulated by a single intravenous injection of glucose or chlorpropamide in rats.
    Endocrinol Jpn. 1966 Dec;13(4):358-83 PMID: 5339782
  15. Junctional complexes in various epithelia.
    J Cell Biol. 1963 May;17:375-412 PMID: 13944428
  16. Polarized intracellular particle transport: saltatory movements and cytoplasmic streaming.
    Int Rev Cytol. 1972;32:93-137 PMID: 4114619
  17. Fracture faces of frozen membranes.
    Proc Natl Acad Sci U S A. 1966 May;55(5):1048-56 PMID: 5334198
  18. [Ultrastructure of cells of the endocrine pancreas in embryonic and newborn rats].
    J Ultrastruct Res. 1957 Nov;1(1):14-25 PMID: 13482037
  19. Similar structural bases for the storage and release of secretory material in adreno-medullary and beta-pancreatic cells.
    Z Zellforsch Mikrosk Anat. 1966;74(3):317-24 PMID: 5986584
  20. A differential stain for cell types in the pancreatic islets.
    Am J Pathol. 1939 Jul;15(4):497-499.2 PMID: 19970466
  21. Studies on insulin biosynthesis. Subcellular distribution of leucine-H3 radioactivity during incubation of goosefish islet tissue.
    J Cell Biol. 1966 Mar;28(3):413-21 PMID: 5335636
  22. Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complex.
    J Cell Biol. 1967 Aug;34(2):577-96 PMID: 6035647
  23. [The autonomous nervous system and the B-cell: metabolic and morphological observations made in spiny mice (Acomys cahirinus) and in cultured fetal rat pancreas].
    Acta Diabetol Lat. 1970 Sep;7 Suppl 1:184-228 PMID: 4919942
  24. Exocytosis-endocytosis coupling in the pancreatic beta cell.
    Science. 1973 Aug 10;181(4099):561-2 PMID: 4578606
  25. Junctions between cancer cells in culture: ultrastructure and permeability.
    Science. 1971 Nov 12;174(4010):717-9 PMID: 4330805
  26. The ultrastructure of endocrine glands.
    Recent Prog Horm Res. 1969;25:315-80 PMID: 4900736
  27. New hypothesis of insulin secretion.
    Nature. 1968 Sep 14;219(5159):1177-9 PMID: 4877537
  28. Diabetic syndrome in sand rats. IV. Morphologic changes in islet tissue.
    Diabetologia. 1967 Apr;3(2):143-66 PMID: 4907138
  29. Structural coupling between pancreatic islet cells.
    Experientia. 1973 Aug 15;29(8):1015-8 PMID: 4582082
  30. Aldehyde-fuchsin: a new stain for elastic tissue.
    Am J Clin Pathol. 1950 Jul;20(7):665-6 PMID: 15432365
  31. Electron microscopy of the beta cell of the pancreas.
    Am J Med. 1961 Dec;31:851-9 PMID: 14461448
  32. Isolation and properties of secretory granules from rat islets of Langerhans. I. Isolation of a secretory granule fraction.
    J Cell Biol. 1969 Apr;41(1):154-61 PMID: 4887227
  33. [Ultrastructural events associated with the action of tolbutamide and glybenclamide on pancreatic B-cells in vivo and in vitro].
    Acta Diabetol Lat. 1969 Sep;6 Suppl 1:271-374 PMID: 4906021
  34. The uptake of exogenous peroxidase by the beta cells of the islets of Langerhans.
    Am J Pathol. 1970 May;59(2):225-46 PMID: 4910240
  35. The ultrastructure of the nexus. A correlated thin-section and freeze-cleave study.
    J Cell Biol. 1970 Dec;47(3):666-88 PMID: 5531667
  36. Electron microscopy of the rat pancreas; effects of glucagon administration.
    Diabetes. 1959 Jan-Feb;8(1):36-44 PMID: 13619489
  37. Acid phosphatase activity in secretory granules of pancreatic beta cells of normal rats.
    Diabetes. 1971 Jun;20(6):385-8 PMID: 4104173
  38. Electron microscopy of structural detail in frozen biological specimens.
    J Biophys Biochem Cytol. 1957 Jan 25;3(1):45-60 PMID: 13416310
  39. Preservation of intercellular substances by the cationic dye alcian blue in preparative procedures for electron microscopy.
    J Ultrastruct Res. 1970 Jun;31(5-6):424-8 PMID: 4196083
  40. Electron microscopic radioautography of thin sections: the Golgi zone as a site of protein concentration in pancreatic acinar cells.
    J Biophys Biochem Cytol. 1961 May;10:37-45 PMID: 13690905
  41. A fine structural analysis of intercellular junctions in the mouse liver.
    J Cell Biol. 1970 May;45(2):272-90 PMID: 4105112
  42. Electron microscopy of the normal islets of Langerhans; studies in the dog, rabbit, guinea pig and rat.
    Diabetes. 1957 Nov-Dec;6(6):498-507 PMID: 13473645
  43. OSMIUM IMPREGNATION OF THE GOLGI APPARATUS.
    Am J Anat. 1965 Jul;117:135-49 PMID: 14345830
  44. PROTEIN SYNTHESIS, STORAGE, AND DISCHARGE IN THE PANCREATIC EXOCRINE CELL. AN AUTORADIOGRAPHIC STUDY.
    J Cell Biol. 1964 Mar;20:473-95 PMID: 14128049
  45. Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen granules.
    J Cell Biol. 1967 Aug;34(2):597-615 PMID: 6035648
  46. Insulin release by emiocytosis: demonstration with freeze-etching technique.
    Science. 1973 Jan 5;179(4068):82-4 PMID: 4565325
  47. Synthesis and migration of proteins in the cells of the exocrine pancreas as revealed by specific activity determination from radioautographs.
    J Cell Biol. 1963 Jan;16:1-24 PMID: 13999005
  48. Morphological and histochemical aspects of glycoproteins at the surface of animal cells.
    Int Rev Cytol. 1971;31:57-114 PMID: 4110370
  49. Electron microscopy of the islets of Langerhans.
    Ann N Y Acad Sci. 1959 Sep 25;82:287-301 PMID: 14413365
  50. Permeability and structure of junctional membranes at an electrotonic synapse.
    Science. 1969 Dec 26;166(3913):1641-3 PMID: 5360587
  51. A comparative study of freeze-etch replicas and thin sections of rat liver.
    J Ultrastruct Res. 1971 Apr;35(1):1-19 PMID: 4931424
  52. Ultrastructural changes in islets of the rat produced by tolbutamide.
    Diabetes. 1961 Nov-Dec;10:460-9 PMID: 14007249
  53. A specialized membrane junction between nerve endings and B-cells in islets of Langerhans.
    Eur J Clin Invest. 1973 Dec;3(6):443-5 PMID: 4591557
Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
Published
1974-06-00
Pages
163-87
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com