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PMID: 3261978 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Metabolism of inositol 1,3,4,5-tetrakisphosphate by human erythrocyte membranes. A new mechanism for the formation of inositol 1,4,5-trisphosphate.

The Biochemical journal ·Vol. 251 ·No. 3 ·1988-05-01 ·Pages 927-9

Doughney C, McPherson MA, Dormer RL

Abstract

Human erythrocyte membranes metabolize inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] to inositol 1,3,4-trisphosphate [Ins(1,3,4)P3] in the presence of Mg2+. In the absence of Mg2+ a less rapid conversion of Ins(1,3,4,5)P4 into Ins(1,4,5)P3 was revealed. Such an enzyme activity, if present in hormonally sensitive cells, could provide a mechanism for maintaining constant concentrations of Ins(1,4,5)P3 and Ins(1,3,4,5)P4, important for stimulation of Ca2+ entry after Ca2+ mobilization.

MeSH Terms
Erythrocyte Membrane/drug effects,metabolism Humans Inositol 1,4,5-Trisphosphate Inositol Phosphates/blood Magnesium/pharmacology Sugar Phosphates/blood
Chemicals
Inositol Phosphates Sugar Phosphates inositol-1,3,4,5-tetrakisphosphate Inositol 1,4,5-Trisphosphate Magnesium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Doughney C
Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, U.K.
McPherson M A
Dormer R L
References (21)
21 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2510927
Published
1988-05-01
Pages
927-9
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1149091
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2510927 PMC Full Text View journal details
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