Home LiteratureArticle Details
PMID: 3163410 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene.

Molecular and cellular biology ·Vol. 8 ·No. 3 ·1988-03-00 ·Pages 1123-31

Burch JB, Evans MI, Friedman TM, O'Malley PJ

Abstract

We used a transient-expression assay to identify two estrogen response elements (EREs) associated with the major chicken vitellogenin gene (VTGII). Each element was characterized by its ability to confer estrogen responsiveness when cloned in either orientation next to a chimeric reporter gene consisting of the herpes simplex virus thymidine kinase promoter and the chloramphenicol acetyl transferase-coding region. Deletion analyses indicated that sequences necessary for the distal ERE resided within the region from -626 to -613 (nucleotide positions relative to the VTGII start site) whereas those necessary for the proximal ERE were within the region from -358 to -335. These distal and proximal elements contain, respectively, a perfect copy and an imperfect copy of the 13-base-pair sequence that is an essential feature of the EREs associated with two frog vitellogenin genes. These chicken VTGII EREs mapped near regions that were restructured at the chromatin level when the endogenous VTGII gene was expressed in the liver in response to estradiol. These data suggest a model for the tissue-specific expression of this estrogen-responsive gene.

MeSH Terms
Acetyltransferases/genetics Animals Base Sequence Cell Line Chickens Chloramphenicol O-Acetyltransferase Cloning, Molecular Estrogens/metabolism Genes Plasmids Promoter Regions, Genetic Thymidine Kinase/genetics Vitellogenins/genetics
Chemicals
Estrogens Vitellogenins Acetyltransferases Chloramphenicol O-Acetyltransferase Thymidine Kinase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Burch J B
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Evans M I
Friedman T M
O'Malley P J
References (46)
46 references, click to expand
  1. Introduction of estrogen-responsiveness into mammalian cell lines.
    Nucleic Acids Res. 1986 Dec 9;14(23):9329-37 PMID: 3467302
  2. Coordinated assembly of the developing egg.
    Bioessays. 1986 May;4(5):197-201 PMID: 2431685
  3. Cell-specificity of the chicken ovalbumin and conalbumin promoters.
    EMBO J. 1987 Aug;6(8):2305-12 PMID: 3665876
  4. The chicken ovalbumin promoter is under negative control which is relieved by steroid hormones.
    EMBO J. 1987 Aug;6(8):2313-20 PMID: 3665877
  5. Developmental regulation of the estrogen receptor and the estrogen responsiveness of five yolk protein genes in the avian liver.
    Proc Natl Acad Sci U S A. 1987 Dec;84(23):8493-7 PMID: 3479803
  6. Isolation of chicken vitellogenin I and III cDNAs and the developmental regulation of five estrogen-responsive genes in the embryonic liver.
    Genes Dev. 1988 Jan;2(1):116-24 PMID: 3356336
  7. Studies on the mechanism of steroid hormone regulation of synthesis of specific proteins.
    Recent Prog Horm Res. 1969;25:105-60 PMID: 4902947
  8. A new technique for the assay of infectivity of human adenovirus 5 DNA.
    Virology. 1973 Apr;52(2):456-67 PMID: 4705382
  9. Estrogen-induced phosphoprotein synthesis in roosters. Kinetics of induction.
    Biochim Biophys Acta. 1973 Feb 4;294(1):497-506 PMID: 4705998
  10. Comparative study of estrogen action.
    Mol Pharmacol. 1973 Jul;9(4):520-33 PMID: 4725783
  11. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
    Anal Biochem. 1976 May 7;72:248-54 PMID: 942051
  12. Hormonal control of vitellogenin synthesis in avian liver.
    Mol Cell Endocrinol. 1976 Jun-Jul;5(1-2):41-50 PMID: 955247
  13. Development of methods for the quantitative in vitro analysis of androgen-dependent and autonomous Shionogi carcinoma 115 cells.
    Cell. 1977 Jan;10(1):35-44 PMID: 837442
  14. Relationship of nuclear estrogen receptor levels to induction of ovalbumin and conalbumin mRNA in chick oviduct.
    J Biol Chem. 1977 Mar 25;252(6):2060-8 PMID: 845159
  15. Kinetics of avian vitellogenin messenger RNA induction. Comparison between primary and secondary response to estrogen.
    J Biol Chem. 1977 Nov 25;252(22):7913-5 PMID: 914847
  16. Appearance of vitellogenin mRNA sequences and rate of vitellogenin synthesis in chicken liver following primary and secondary stimulation by 17 beta-estradiol.
    Eur J Biochem. 1978 Mar 15;84(2):355-61 PMID: 639793
  17. Control of cellular content of chicken egg white protein specific RNA during estrogen administration and withdrawal.
    Biochemistry. 1979 Feb 20;18(4):616-24 PMID: 420804
  18. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.
    Science. 1980 Jul 25;209(4455):497-9 PMID: 6248960
  19. A simple, rapid, and sensitive DNA assay procedure.
    Anal Biochem. 1980 Mar 1;102(2):344-52 PMID: 6158890
  20. Steroid hormone regulation of ovalbumin and conalbumin gene transcription. A model based upon multiple regulatory sites and intermediary proteins.
    J Biol Chem. 1981 Aug 10;256(15):7910-6 PMID: 7263632
  21. Steroid hormone regulation of vitellogenin gene expression.
    CRC Crit Rev Biochem. 1982 Mar;12(3):187-203 PMID: 6123408
  22. Transcriptional control signals of a eukaryotic protein-coding gene.
    Science. 1982 Jul 23;217(4557):316-24 PMID: 6283634
  23. Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4252-5 PMID: 6956855
  24. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
    Mol Cell Biol. 1982 Sep;2(9):1044-51 PMID: 6960240
  25. Methylation of the chicken vitellogenin gene: influence of estradiol administration.
    Nucleic Acids Res. 1983 Mar 11;11(5):1361-73 PMID: 6298743
  26. Kinetics of primary and secondary stimulation of the mRNA for APOVLDL-II, a major yolk protein, in the cockerel liver by estrogen.
    Endocrinology. 1983 Sep;113(3):1158-60 PMID: 6872953
  27. A 5'-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene.
    Nature. 1983 Oct 6-12;305(5934):551-4 PMID: 6621702
  28. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene.
    Cell. 1983 Oct;34(3):865-79 PMID: 6313211
  29. Regulated expression of the chicken ovalbumin gene in a human estrogen-responsive cell line.
    J Biol Chem. 1983 Oct 25;258(20):12693-701 PMID: 6313672
  30. Identification and sequence analysis of the 5' end of the major chicken vitellogenin gene.
    Nucleic Acids Res. 1984 Jan 25;12(2):1117-35 PMID: 6694908
  31. Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene.
    Proc Natl Acad Sci U S A. 1984 Jan;81(2):429-33 PMID: 6582498
  32. Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding.
    Cell. 1984 Jun;37(2):503-10 PMID: 6722881
  33. Independent developmental programs for two estrogen-regulated genes.
    Science. 1984 Aug 10;225(4662):639-41 PMID: 6740331
  34. Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene.
    Cell. 1983 May;33(1):65-76 PMID: 6088056
  35. Promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone.
    Recent Prog Horm Res. 1984;40:1-42 PMID: 6091191
  36. Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes.
    Nucleic Acids Res. 1984 Nov 26;12(22):8611-26 PMID: 6504705
  37. Effects of estrogen on apolipoprotein secretion by the human hepatocarcinoma cell line, HepG2.
    J Biol Chem. 1985 Feb 10;260(3):1670-5 PMID: 2981867
  38. Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.
    DNA. 1985 Apr;4(2):165-70 PMID: 3996185
  39. The effects of estrogen on apolipoprotein synthesis.
    Can J Biochem Cell Biol. 1985 Aug;63(8):882-9 PMID: 4063873
  40. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
    Nature. 1986 Mar 13-19;320(6058):134-9 PMID: 3754034
  41. An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.
    Cell. 1986 Sep 26;46(7):1053-61 PMID: 3463433
  42. Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.
    Proc Natl Acad Sci U S A. 1986 Oct;83(19):7167-71 PMID: 3463957
  43. Chromatin structural transitions and the phenomenon of vitellogenin gene memory in chickens.
    Mol Cell Biol. 1986 Jun;6(6):1886-93 PMID: 3785183
  44. Conserved sequence motifs upstream from the co-ordinately expressed vitellogenin and apoVLDLII genes of chicken.
    Nucleic Acids Res. 1986 Nov 11;14(21):8669-80 PMID: 3024115
  45. Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line.
    Nucleic Acids Res. 1986 Nov 25;14(22):8755-70 PMID: 3466137
  46. Electron microscopic visualization of protein-DNA interactions at the estrogen responsive element and in the first intron of the Xenopus laevis vitellogenin gene.
    EMBO J. 1987 Jun;6(6):1715-20 PMID: 3608991
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.8.3.1123-1131.1988
Published
1988-03-00
Pages
1123-31
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363255
Subset
IM
Grants
NCI NIH HHS · CA-09035 · United States
NCI NIH HHS · CA06927 · United States
NIGMS NIH HHS · GM0335 · United States
External Links
PubMed source DOI: 10.1128/mcb.8.3.1123-1131.1988 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2