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PMID: 3024115 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Conserved sequence motifs upstream from the co-ordinately expressed vitellogenin and apoVLDLII genes of chicken.

Nucleic acids research ·Vol. 14 ·No. 21 ·1986-11-11 ·Pages 8669-80

van het Schip F, Strijker R, Samallo J, Gruber M, Geert AB

Abstract

The vitellogenin and apoVLDLII yolk protein genes of chicken are transcribed in the liver upon estrogenization. To get information on putative regulatory elements, we compared more than 2 kb of their 5' flanking DNA sequences. Common sequence motifs were found in regions exhibiting estrogen-induced changes in chromatin structure. Stretches of alternating pyrimidines and purines of about 30-nucleotides long are present at roughly similar positions. A distinct box of sequence homology in the chicken genes also appears to be present at a similar position in front of the vitellogenin genes of Xenopus laevis, but is absent from the estrogen-responsive egg-white protein genes expressed in the oviduct. In front of the vitellogenin (position -595) and the VLDLII gene (position -548), a DNA element of about 300 base-pairs was found, which possesses structural characteristics of a mobile genetic element and bears homology to the transposon-like Vi element of Xenopus laevis.

MeSH Terms
Animals Apolipoproteins/genetics Base Sequence Chickens DNA Restriction Enzymes Female Genes Lipoproteins, VLDL/genetics Liver/metabolism Oviducts/metabolism Transcription, Genetic Vitellogenins/genetics Xenopus
Chemicals
Apolipoproteins Lipoproteins, VLDL Vitellogenins apolipoprotein VLDL II DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
van het Schip F
Strijker R
Samallo J
Gruber M
Geert A B
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39 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.21.8669
Published
1986-11-11
Pages
8669-80
Language
English
Region
England
NLM ID
0411011
PMCID
PMC311885
Subset
IM
Databases
GENBANK
X04593, X04594
External Links
PubMed source DOI: 10.1093/nar/14.21.8669 PMC Full Text View journal details
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