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PMID: 3106640 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular evolution of the Saccharomyces cerevisiae histone gene loci.

Journal of molecular evolution ·Vol. 24 ·No. 3 ·1987-00-00 ·Pages 252-9

Smith MM

Abstract

The core histone genes of Saccharomyces cerevisiae are arranged as duplicate nonallelic sets of specifically paired genes. The identity of structural organization between the duplicated gene pairs would have its simplest evolutionary origin in the duplication of a complete locus in a single event. In such a case, the time since the duplication of one of the genes should be identical to that since duplication of the gene adjacent to it on the chromosome. A calculation of the evolutionary distances between the coding DNA sequences of the histone genes leads to a duplication paradox: The extents of sequence divergence in the silent component of third-base positions for adjacent pairs of genes are not identical. Estimates of the evolutionary distance between the two H3-H4 noncoding intergene DNA sequences are large; the divergence between the two separate sequences is indistinguishable from the divergence between either of the regions and a randomly generated permutation of itself. These results suggest that the duplication event may have occurred much earlier than previously estimated. The potential age of the duplication, and the attractive simplicity of the duplication of both the H3-H4 and the H2A-H2B gene pairs having taken place in a single event, leads to the hypothesis that modern haploid S. cerevisiae may have evolved by diploidization or fusion of two ancient fungi.

MeSH Terms
Base Sequence Biological Evolution Diploidy Genes Genes, Fungal Histones/genetics Saccharomyces cerevisiae/genetics Schizosaccharomyces/genetics Sequence Homology, Nucleic Acid
Chemicals
Histones
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Smith M M
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44 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02111238
Published
1987-00-00
Pages
252-9
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
Grants
NIGMS NIH HHS · GM28920 · United States
External Links
PubMed source DOI: 10.1007/BF02111238 View journal details
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