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PMID: 6251545 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Recombination of dispersed repeated DNA sequences in yeast.

Science (New York, N.Y.) ·Vol. 209 ·No. 4463 ·1980-09-19 ·Pages 1380-4

Scherer S, Davis RW

Abstract

Yeast transformation can be used to insert new sequence arrangements into a variety of chromosomal locations by homologous recombination. These newly inserted sequences can recombine with similar sequences located on other chromosomes. In these events, information is duplicated without being lost at the site from which it is derived. Similar mechanisms might be utilized by cells to provide new functions during development or differentiation.

MeSH Terms
Base Sequence Chromosome Deletion Chromosomes/ultrastructure DNA Transposable Elements DNA, Fungal/genetics Gene Conversion Histidine/genetics Recombination, Genetic Saccharomyces cerevisiae/genetics Transformation, Genetic
Chemicals
DNA Transposable Elements DNA, Fungal Histidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Scherer S
Davis R W
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1980-09-19
Pages
1380-4
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIGMS NIH HHS · GM21891 · United States
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