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PMID: 3094007 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Assignment of the human and mouse prion protein genes to homologous chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 19 ·1986-10-00 ·Pages 7358-62

Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T

Abstract

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12----pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.

MeSH Terms
Animals Chromosome Mapping Chromosomes, Human, Pair 20 Humans Mice Prions/genetics
Chemicals
Prions
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Sparkes R S
Simon M
Cohn V H
Fournier R E
Lem J
Klisak I
Heinzmann C
Blatt C
Lucero M
Mohandas T
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.19.7358
Published
1986-10-00
Pages
7358-62
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386716
Subset
IM
Grants
NIGMS NIH HHS · GM26449 · United States
NINDS NIH HHS · NS22786 · United States
NINDS NIH HHS · T32 NS07149 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.19.7358 PMC Full Text View journal details
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