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PMID: 3090454 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 332 ·No. 4 ·1986-04-00 ·Pages 403-5

Böhm M, Brückner R, Neumann J, Schmitz W, Scholz H, Starbatty J

Abstract

In atrial cardiac preparations adenosine exerts a receptor-mediated negative inotropic effect due to an increased potassium conductance. Pretreatment of guinea pigs with pertussis toxin abolished the negative inotropic and action potential shortening effect of adenosine and the adenosine analogue (-)-N6-phenylisopropyladenosine (PIA). As pertussis toxin specifically inactivates guanine nucleotide-binding proteins involved in the signal transfer from receptor binding to specific cell functions, it is concluded that a guanine nucleotide-binding protein is involved in the regulation of the receptor-mediated change in potassium conductance and force of contraction.

MeSH Terms
Action Potentials/drug effects Adenosine/analogs & derivatives,antagonists & inhibitors,pharmacology Animals GTP-Binding Proteins/physiology Guinea Pigs Heart Atria In Vitro Techniques Myocardial Contraction/drug effects Pertussis Toxin Phenylisopropyladenosine/antagonists & inhibitors,pharmacology Potassium/physiology Virulence Factors, Bordetella/pharmacology
Chemicals
Virulence Factors, Bordetella Phenylisopropyladenosine Pertussis Toxin GTP-Binding Proteins Adenosine Potassium
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Böhm M
Brückner R
Neumann J
Schmitz W
Scholz H
Starbatty J
References (17)
17 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00500095
Published
1986-04-00
Pages
403-5
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00500095 View journal details
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