Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.

Experientia ·Vol. 39 ·No. 12 ·1983-12-15 ·Pages 1347-9

Jochem G, Nawrath H

Abstract

Adenosine shortens the action potential and diminishes the force of contraction in guinea-pig left atria. These effects may be brought about by the activation of a potassium conductance. This assumption is supported by voltage clamp and 42K release experiments.

MeSH Terms

Action Potentials/drug effects Adenosine/pharmacology Animals Electric Conductivity Guinea Pigs Heart/physiology Heart Atria Myocardial Contraction/drug effects Potassium/metabolism

Chemicals

Adenosine Potassium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jochem G

Nawrath H

References (17)

17 references, click to expand

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Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01990096

Published

1983-12-15

Pages

1347-9

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01990096

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Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.

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