Islet-activating protein, pertussis toxin, inhibits Ca2+-induced and guanine nucleotide-dependent releases of histamine and arachidonic acid from rat mast cells.

Adenylate Cyclase Toxin Adenylyl Cyclases/metabolism Animals Arachidonic Acid Arachidonic Acids/metabolism Bacterial Proteins/pharmacology Bacterial Toxins/pharmacology Calcium/pharmacology GTP-Binding Proteins Guanosine Triphosphate/analogs & derivatives Guanylyl Imidodiphosphate/pharmacology Histamine Release/drug effects In Vitro Techniques Kinetics Mast Cells/drug effects,immunology,physiology Pertussis Toxin Rats Receptors, Cell Surface/metabolism Virulence Factors, Bordetella

Adenylate Cyclase Toxin Arachidonic Acids Bacterial Proteins Bacterial Toxins Receptors, Cell Surface Virulence Factors, Bordetella Arachidonic Acid Guanylyl Imidodiphosphate Guanosine Triphosphate Pertussis Toxin GTP-Binding Proteins Adenylyl Cyclases Calcium