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PMID: 3037547 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 15 ·1987-08-00 ·Pages 5384-8

Thorley-Lawson DA, Israelsohn ES

Abstract

Human B lymphocytes, transformed by the herpesvirus Epstein-Barr virus, are known to express a characteristic antigen(s) recognized by the cellular immune response. This structure has been termed lymphocyte-determined membrane antigen. Because of the significance of this structure in controlling Epstein-Barr virus infection in vivo, the molecular nature of lymphocyte-determined membrane antigen has been long sought. In this paper, we show that a sequence of 10 amino acids (residues 43-53) from the Epstein-Barr virus-encoded membrane protein p63/latent membrane protein can induce Epstein-Barr virus-specific cytotoxic T cells and, therefore, bears at least one of the lymphocyte-determined membrane antigenic determinants.

MeSH Terms
B-Lymphocytes/immunology Cell Division Cell Line Cell Transformation, Viral Herpesvirus 4, Human/analysis Humans Immunity, Cellular T-Lymphocytes, Cytotoxic/immunology Viral Matrix Proteins Viral Proteins/immunology
Chemicals
Viral Matrix Proteins Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thorley-Lawson D A
Israelsohn E S
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.15.5384
Published
1987-08-00
Pages
5384-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298860
Subset
IM
Grants
NIAID NIH HHS · AI 00549 · United States
NIAID NIH HHS · AI 15310 · United States
NCI NIH HHS · CA 28737 · United States
External Links
PubMed source DOI: 10.1073/pnas.84.15.5384 PMC Full Text View journal details
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