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PMID: 3009821 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The role of phosphoinositides in signal transduction.

The Journal of membrane biology ·Vol. 89 ·No. 3 ·1986-00-00 ·Pages 193-210

Sekar MC, Hokin LE

Abstract

暂无摘要

MeSH Terms
Animals Arachidonic Acid Arachidonic Acids/metabolism Calcium/metabolism Cell Division Diglycerides/metabolism Kinetics Lithium/pharmacology Models, Biological Oncogenes Phosphatidylinositol Phosphates Phosphatidylinositols/physiology Phosphorylation Protein Kinase C/metabolism Receptors, Drug/physiology
Chemicals
Arachidonic Acids Diglycerides Phosphatidylinositol Phosphates Phosphatidylinositols Receptors, Drug Arachidonic Acid Lithium Protein Kinase C Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sekar M C
Hokin L E
References (312)
312 references, click to expand
  1. Stimulated inositol lipid metabolism: an introduction.
    Cell Calcium. 1982 Oct;3(4-5):285-94 PMID: 6297737
  2. A direct demonstration that inositol-trisphosphate induces an increase in intracellular calcium in Limulus photoreceptors.
    Biochem Biophys Res Commun. 1984 Dec 28;125(3):1137-42 PMID: 6335035
  3. Calcium-phospholipid interactions in secretory cells: a new perspective on stimulus-secretion coupling.
    Fed Proc. 1982 Apr;41(6):2181-7 PMID: 6281077
  4. Receptor occupancy dose--response curve suggests that phosphatidyl-inositol breakdown may be intrinsic to the mechanism of the muscarinic cholinergic receptor.
    FEBS Lett. 1976 Oct 15;69(1):1-5 PMID: 992019
  5. The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells.
    J Biol Chem. 1981 May 25;256(10 ):5215-9 PMID: 6785279
  6. Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils.
    Biochem Biophys Res Commun. 1983 May 16;112(3):957-64 PMID: 6303343
  7. A difference in the breakdown of phosphatidylinositol in normal and SV40 transformed mouse fibroblasts.
    Biochem Biophys Res Commun. 1973 Nov 16;55(2):305-11 PMID: 4358397
  8. Phospholipids as intermediates in hormone action.
    Mol Cell Endocrinol. 1984 Apr;35(1):1-14 PMID: 6143700
  9. Rapid protein phosphorylation induced by phorbol ester in HL-60 cells. Unique alkali-stable phosphorylation of a 17,000-dalton protein detected by two-dimensional gel electrophoresis.
    J Biol Chem. 1983 Sep 10;258(17):10786-93 PMID: 6577004
  10. Enhanced turnover of arachidonic acid-containing species of phosphatidylinositol and phosphatidic acid of concanavalin A-stimulated lymphocytes.
    Biochim Biophys Acta. 1984 Nov 14;796(2):190-8 PMID: 6498210
  11. Regulation of phosphatidate synthesis by secretagogues in parotid acinar cells.
    Biochem J. 1982 May 15;204(2):587-92 PMID: 6180740
  12. Polyphosphoinositide hydrolysis by phospholipase C is accelerated by thyrotropin releasing hormone (TRH) in clonal rat pituitary cells (GH3 cells).
    FEBS Lett. 1984 Mar 12;168(1):54-60 PMID: 6323219
  13. Modification of glycogen synthase activity in isolated rat hepatocytes by tumor-promoting phorbol esters: evidence for differential regulation of glycogen synthase and phosphorylase.
    Proc Natl Acad Sci U S A. 1983 Dec;80(23):7170-2 PMID: 6417664
  14. TPA-induced contraction of isolated rabbit vascular smooth muscle.
    Biochem Biophys Res Commun. 1984 Jul 31;122(2):776-84 PMID: 6431975
  15. The effect of inositol trisphosphate on Ca2+ fluxes in insulin-secreting tumor cells.
    J Biol Chem. 1984 Nov 10;259(21):12952-5 PMID: 6092355
  16. Phosphatidate as a molecular link between depolarization and neurotransmitter release in the brain.
    Science. 1981 Jun 12;212(4500):1290-1 PMID: 7233220
  17. Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.
    J Biol Chem. 1983 May 10;258(9):5716-25 PMID: 6304096
  18. Phospholipid precursors of prostaglandins.
    Biochim Biophys Acta. 1968 Oct 22;164(2):426-9 PMID: 5721037
  19. Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function.
    Biochem Biophys Res Commun. 1984 Aug 30;123(1):64-70 PMID: 6433920
  20. RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes.
    Prostaglandins. 1984 May;27(5):673-82 PMID: 6431499
  21. Inositol phospholipids and cell surface receptor function.
    Biochim Biophys Acta. 1975 Mar 25;415(1):81-47 PMID: 164246
  22. Phorbol ester-induced protein secretion in rat parotid gland. Relationship to the role of inositol lipid breakdown and protein kinase C activation in stimulus-secretion coupling.
    Mol Pharmacol. 1984 Sep;26(2):261-6 PMID: 6237255
  23. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
    J Biol Chem. 1980 Mar 25;255(6):2273-6 PMID: 7358670
  24. Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.
    J Biol Chem. 1983 Dec 25;258(24):14816-22 PMID: 6317674
  25. Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland.
    Biochem J. 1979 Jan 15;178(1):45-58 PMID: 219851
  26. Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate.
    Biochem J. 1977 Jan 15;162(1):61-73 PMID: 192213
  27. Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.
    Pharmacol Rev. 1978 Sep;30(3):293-331 PMID: 116251
  28. Inositol trisphosphates in carbachol-stimulated rat parotid glands.
    Biochem J. 1984 Oct 1;223(1):237-43 PMID: 6333870
  29. Activation of phospholipase C in thrombin-stimulated platelets does not depend on cytoplasmic free calcium concentration.
    FEBS Lett. 1984 May 7;170(1):43-8 PMID: 6327376
  30. Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.
    J Biol Chem. 1981 Jun 10;256(11):5399-403 PMID: 7240145
  31. Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.
    FEBS Lett. 1984 May 7;170(1):64-8 PMID: 6202551
  32. Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands.
    Biochem J. 1979 Jun 15;180(3):655-61 PMID: 486139
  33. Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.
    J Biol Chem. 1981 Mar 25;256(6):2736-41 PMID: 6782095
  34. Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.
    J Biol Chem. 1984 Jul 10;259(13):8066-9 PMID: 6610677
  35. Thrombin-induced protein phosphorylation in human platelets.
    J Clin Invest. 1975 Oct;56(4):924-36 PMID: 169298
  36. Steroidogenic properties of phorbol ester and a Ca2+ ionophore in bovine adrenocortical cell suspensions.
    Biochem Biophys Res Commun. 1984 Jun 15;121(2):499-506 PMID: 6233977
  37. Increased brain myo-inositol 1-phosphate in lithium-treated rats.
    Biochem Biophys Res Commun. 1976 Jul 26;71(2):664-70 PMID: 962945
  38. Phospholipid methylation and biological signal transmission.
    Science. 1980 Sep 5;209(4461):1082-90 PMID: 6157192
  39. Widespread occurrence of calcium-activated, phospholipid-dependent protein kinase in mammalian tissues.
    J Biochem. 1981 May;89(5):1651-4 PMID: 7275959
  40. A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets.
    Biochem Biophys Res Commun. 1982 Oct 29;108(4):1701-8 PMID: 7181916
  41. AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism.
    Biochem Biophys Res Commun. 1982 Jun 15;106(3):697-703 PMID: 6288030
  42. The formation and continuous turnover of a fraction of phosphatidic acid on stimulation of NaC1 secretion by acetylcholine in the salt gland.
    J Gen Physiol. 1967 Mar;50(4):793-811 PMID: 6034504
  43. Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane.
    Nature. 1983 Feb 17-23;301(5901):621-3 PMID: 6828143
  44. Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
    J Biol Chem. 1985 Feb 10;260(3):1358-61 PMID: 3155733
  45. Phorbol myristate acetate stimulates formation of phosphatidyl inositol 4-phosphate and phosphatidyl inositol 4,5-bisphosphate in human platelets.
    Biochem Biophys Res Commun. 1984 Oct 30;124(2):507-13 PMID: 6093804
  46. Inositol lipids and cell stimulation in mammalian salivary gland.
    Cell Calcium. 1982 Oct;3(4-5):369-83 PMID: 6297740
  47. Hormonal stimulation of arachidonate release from isolated perfused organs. Relationship to prostaglandin biosynthesis.
    Prostaglandins. 1977 Nov;14(5):853-71 PMID: 594388
  48. THE ENZYMATIC FORMATION OF PROSTAGLANDIN E2 FROM ARACHIDONIC ACID PROSTAGLANDINS AND RELATED FACTORS 32.
    Biochim Biophys Acta. 1964 Jul 15;90:207-10 PMID: 14201168
  49. Synergism between phorbol ester and A23187 in superoxide production by neutrophils.
    FEBS Lett. 1984 Sep 17;175(1):170-2 PMID: 6090208
  50. Arachidonic acid inhibits thyrotropin-releasing hormone-induced elevation of cytoplasmic free calcium in GH3 pituitary cells.
    J Biol Chem. 1985 Jan 25;260(2):707-13 PMID: 3918031
  51. Lipase activity against 1,2-diglyceride in rat erythrocyte membranes.
    Biochem J. 1971 Oct;124(5):49P-50P PMID: 5130985
  52. Radioautographic localization of the increased synthesis of phosphatidylinositol in response to pancreozymin or acetylcholine in guinea pig pancreas slices.
    J Cell Biol. 1967 Jun;33(3):521-30 PMID: 4292091
  53. The effects of alpha 1-adrenergic and muscarinic cholinergic stimulation on prostaglandin release by rabbit iris.
    Prostaglandins. 1984 Sep;28(3):399-415 PMID: 6440215
  54. Endogenous phosphorylation of retinal photoreceptor outer segment proteins by calcium phospholipid-dependent protein kinase.
    Biochem Biophys Res Commun. 1984 Aug 16;122(3):1397-403 PMID: 6236809
  55. Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.
    Proc Natl Acad Sci U S A. 1982 Jul;79(13):3935-9 PMID: 6287453
  56. Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells.
    Biochem J. 1984 Oct 15;223(2):467-73 PMID: 6093775
  57. Arachidonate release and phosphatidic acid turnover in stimulated human platelets.
    J Biol Chem. 1983 Feb 25;258(4):2461-7 PMID: 6401733
  58. Platelet activating factor (PAF-acether) promotes an early degradation of phosphatidylinositol-4,5-biphosphate in rabbit platelets.
    FEBS Lett. 1983 Mar 21;153(2):361-5 PMID: 6311620
  59. Oncogenes, ions, and phospholipids.
    Am J Physiol. 1985 Jan;248(1 Pt 1):C3-11 PMID: 2578254
  60. Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation.
    Biochem J. 1984 Sep 1;222(2):351-61 PMID: 6477519
  61. The phosphatidate-phosphoinositide cycle: an intracellular messenger system in the action of hormones and neurotransmitters.
    Metabolism. 1983 Jun;32(6):628-41 PMID: 6133206
  62. Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.
    J Biol Chem. 1981 Nov 10;256(21):10945-8 PMID: 6270138
  63. A possible role of stimulus-enhanced phosphatidylinositol turnover: calcium-sparing effect of diacylglycerol in inducing phase separation of phosphatidyl-choline/phosphatidylserine mixtures.
    Biochem Biophys Res Commun. 1981 May 15;100(1):321-7 PMID: 6266405
  64. The role of calcium in phospholipid turnover following glucose stimulation in neonatal rat cultured islets.
    J Biol Chem. 1984 Jul 10;259(13):8407-11 PMID: 6376506
  65. sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.
    J Biol Chem. 1985 Feb 10;260(3):1562-6 PMID: 2981862
  66. Light- and cytidine-dependent phosphatidylinositol synthesis in photoreceptor cells of the rat.
    J Cell Biol. 1983 Sep;97(3):832-7 PMID: 6885920
  67. The enzymatic synthesis of inositol phosphatide.
    J Biol Chem. 1958 Nov;233(5):1077-83 PMID: 13598735
  68. Phorbol diester receptor copurifies with protein kinase C.
    Proc Natl Acad Sci U S A. 1983 Jan;80(1):36-40 PMID: 6296873
  69. Diphosphoinositide metabolism in bovine adrenal medulla.
    Can J Biochem. 1976 Aug;54(8):746-53 PMID: 182344
  70. Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol phosphates.
    Biochem J. 1984 Nov 15;224(1):291-300 PMID: 6095818
  71. Receptors and phosphoinositide-generated second messengers.
    Annu Rev Biochem. 1985;54:205-35 PMID: 2992357
  72. Acetylcholine and the exchange of inositol and phosphate in brain phosphoinositide.
    J Biol Chem. 1958 Oct;233(4):818-21 PMID: 13587499
  73. Synergistic stimulation of prolactin release by phorbol ester, A23187 and forskolin.
    Biochem Biophys Res Commun. 1984 Sep 17;123(2):735-41 PMID: 6091639
  74. Diacylglycerol causes major structural transitions in phospholipid bilayer membranes.
    Biochem Biophys Res Commun. 1984 Oct 30;124(2):491-6 PMID: 6541910
  75. Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.
    Biochem Biophys Res Commun. 1984 Jun 15;121(2):573-8 PMID: 6203533
  76. Arachidonate metabolism in vascular disorders.
    J Clin Invest. 1983 Nov;72(5):1521-5 PMID: 6313764
  77. The action of prostaglandin synthetase on 2-arachidonyl-lecithin.
    Biochim Biophys Acta. 1968 Oct 22;164(2):430-2 PMID: 5721038
  78. Fertilization increases the polyphosphoinositide content of sea urchin eggs.
    Nature. 1984 Aug 2-8;310(5976):414-5 PMID: 6087155
  79. Polyphosphoinositide metabolism in excitable membranes. Review.
    Biosci Rep. 1983 Oct;3(10 ):887-904 PMID: 6317077
  80. Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.
    J Biol Chem. 1984 Nov 25;259(22):13652-5 PMID: 6438079
  81. In vitro stimulation of prostaglandin synthesis in the rat pancreas by carbamylcholine, caerulein and secretin.
    Prostaglandins. 1981 Jul;22(1):35-51 PMID: 6945632
  82. An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor).
    Arch Biochem Biophys. 1983 Dec;227(2):626-9 PMID: 6320731
  83. Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
    Arch Biochem Biophys. 1983 May;223(1):33-9 PMID: 6407399
  84. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
    Nature. 1983 Nov 3-9;306(5938):67-9 PMID: 6605482
  85. Secretagogue-induced phosphoinositide metabolism in human leucocytes.
    Biochem J. 1984 Sep 1;222(2):307-14 PMID: 6089766
  86. Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.
    J Biol Chem. 1983 Jan 10;258(1):227-34 PMID: 6401292
  87. Phospholipid metabolism in stimulated human platelets. Changes in phosphatidylinositol, phosphatidic acid, and lysophospholipids.
    J Clin Invest. 1980 Aug;66(2):275-83 PMID: 7400315
  88. Effects of various mitogens on the phospholipid metabolism of human peripheral lymphocytes.
    Biochim Biophys Acta. 1973 Dec 20;326(3):339-44 PMID: 4359864
  89. Effects of luteinizing hormone on phosphoinositide metabolism in rat granulosa cells.
    J Biol Chem. 1984 Dec 25;259(24):15028-34 PMID: 6096354
  90. Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas.
    J Membr Biol. 1984;81(3):241-53 PMID: 6334162
  91. (poly) Phosphoinositide phosphorylation is a marker for plasma membrane in Friend erythroleukaemic cells.
    FEBS Lett. 1982 Nov 1;148(1):140-4 PMID: 6959824
  92. Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets.
    Nature. 1983 Sep 22-28;305(5932):317-9 PMID: 6621685
  93. Thyrotropin-releasing hormone stimulates rapid breakdown of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in GH3 pituitary tumor cells.
    Mol Pharmacol. 1984 Mar;25(2):193-200 PMID: 6321942
  94. Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore.
    Biochem Biophys Res Commun. 1984 Jul 31;122(2):734-9 PMID: 6087812
  95. Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
    Proc Natl Acad Sci U S A. 1984 Apr;81(7):2117-21 PMID: 6326105
  96. 12-O-Tetradecanoylphorbol 13-acetate stimulates inositol lipid phosphorylation in intact human platelets.
    FEBS Lett. 1984 Aug 6;173(2):389-93 PMID: 6235130
  97. The role of hormone receptors and GTP-regulatory proteins in membrane transduction.
    Nature. 1980 Mar 6;284(5751):17-22 PMID: 6101906
  98. What is the function of phospholipid N-methylation?
    Biochem J. 1983 Jul 1;213(1):1-10 PMID: 6311156
  99. The synthesis of phosphatidic acid from diglyceride and adenosine triphosphate in extracts of brain microsomes.
    J Biol Chem. 1959 Jun;234(6):1381-6 PMID: 13654382
  100. The rapid polyphosphoinositide metabolism may be a triggering event for thrombin-mediated stimulation of human platelets.
    Biochem Biophys Res Commun. 1983 Jan 14;110(1):108-15 PMID: 6301436
  101. Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.
    Biochem J. 1983 Jun 15;212(3):733-47 PMID: 6309153
  102. Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267.
    J Biol Chem. 1982 Dec 10;257(23 ):14006-10 PMID: 7142192
  103. Regulation of plasma membrane Ca2+ ATPases by lipids of the phosphatidylinositol cycle.
    Biochem Biophys Res Commun. 1984 Dec 28;125(3):908-15 PMID: 6097254
  104. Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6.
    Proc Natl Acad Sci U S A. 1984 Oct;81(20):6408-12 PMID: 6093101
  105. Localization of enzymes involved in polyphosphoinositids metabolism on the cytoplasmic surface of the human erythrocyte membrane.
    Biochim Biophys Acta. 1975 Feb 28;382(1):58-64 PMID: 164238
  106. Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.
    Proc Natl Acad Sci U S A. 1984 May;81(9):2728-32 PMID: 6326140
  107. Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms.
    Biochem J. 1984 Feb 15;218(1):177-85 PMID: 6324748
  108. The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils.
    Biochem J. 1984 Sep 1;222(2):557-9 PMID: 6477532
  109. Inositol (1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver.
    Biochem Biophys Res Commun. 1984 May 16;120(3):858-64 PMID: 6610417
  110. Dynamic aspects of phospholipids during protein secretion.
    Int Rev Cytol. 1968;23:187-208 PMID: 4872349
  111. Regulation of Ca2+ efflux from kidney and liver mitochondria by unsaturated fatty acids and Na+ ions.
    Eur J Biochem. 1979 Dec 17;102(2):615-23 PMID: 93538
  112. Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium.
    Biochem Biophys Res Commun. 1983 Jul 29;114(2):638-45 PMID: 6411090
  113. Diglyceride lipase: a pathway for arachidonate release from human platelets.
    Proc Natl Acad Sci U S A. 1979 Jul;76(7):3238-41 PMID: 290999
  114. Identification of high-affinity phorbol ester receptor in cytosol of EL4 thymoma cells: requirement for calcium, magnesium, and phospholipids.
    Proc Natl Acad Sci U S A. 1983 May;80(9):2642-6 PMID: 6302698
  115. Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate.
    Biochem J. 1984 Apr 15;219(2):655-9 PMID: 6611151
  116. Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester.
    Biochem Biophys Res Commun. 1984 Jul 18;122(1):158-64 PMID: 6234894
  117. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process.
    Proc Natl Acad Sci U S A. 1977 Oct;74(10):4481-5 PMID: 270695
  118. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
    J Biol Chem. 1982 Jul 10;257(13):7847-51 PMID: 7085651
  119. Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles.
    Biochem Biophys Res Commun. 1980 Nov 28;97(2):759-65 PMID: 7008793
  120. ADP-induced changes in [32P]phosphate labeling of phosphatidylinositol-4,5-bisphosphate in washed rabbit platelets made refractory by prior ADP stimulation.
    Biochem Biophys Res Commun. 1983 Jun 15;113(2):483-90 PMID: 6307289
  121. The effects of secretagogues on the incorporation of (2- 3 H)myoinositol into lipid in cytological fractions in the pancreas of the guinea pig in vivo.
    J Cell Biol. 1973 Mar;56(3):736-45 PMID: 4347208
  122. Triphosphoinositide breakdown and dense body release as the earliest events in thrombin-induced activation of human platelets.
    Biochem Biophys Res Commun. 1983 Oct 31;116(2):513-9 PMID: 6316954
  123. A transient increase in diacylglycerols is associated with the action of vasopressin on hepatocytes.
    Biochem J. 1984 Sep 1;222(2):535-40 PMID: 6477530
  124. Metabolism of arachidonoyl phosphoglycerides in mouse brain subcellular fractions.
    J Neurochem. 1979 Mar;32(3):1053-9 PMID: 430038
  125. Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver.
    Nature. 1984 Nov 22-28;312(5992):374-6 PMID: 6095097
  126. Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase.
    J Pharmacol Exp Ther. 1983 Jul;226(1):180-6 PMID: 6134818
  127. Effects of inositol-1,4,5-trisphosphate injections into salamander rods.
    Biochem Biophys Res Commun. 1985 Jan 16;126(1):59-62 PMID: 3871609
  128. myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.
    J Biol Chem. 1984 Mar 10;259(5):3077-81 PMID: 6607924
  129. Coupling of polyphosphoinositide breakdown with calcium efflux in formyl-methionyl-leucyl-phenylalanine-stimulated rabbit neutrophils.
    FEBS Lett. 1983 Sep 19;161(2):296-300 PMID: 6311626
  130. Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.
    J Biol Chem. 1983 Feb 25;258(4):2076-8 PMID: 6296123
  131. Actions of derivatives of cyclic nucleotides on dispersed acini from guinea pig pancreas. Discovery of a competitive antagonist of the action of cholecystokinin.
    J Biol Chem. 1979 Jun 25;254(12):5321-7 PMID: 221466
  132. The stereospecific activation of protein kinase C.
    Biochem Biophys Res Commun. 1984 Jul 31;122(2):818-23 PMID: 6235812
  133. Arachidonic acid metabolism in isolated pancreatic islets. II. The effects of glucose and of inhibitors of arachidonate metabolism on insulin secretion and metabolite synthesis.
    Biochim Biophys Acta. 1984 Jun 6;794(1):125-36 PMID: 6428455
  134. Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system.
    Biochem Biophys Res Commun. 1979 Dec 28;91(4):1218-24 PMID: 526298
  135. Recent hypotheses regarding the phosphatidylinositol effect.
    Life Sci. 1981 Sep 21;29(12):1183-94 PMID: 7029181
  136. Phosphatidylinositol 4,5-bisphosphate: light-mediated breakdown in the vertebrate retina.
    Biochem Biophys Res Commun. 1984 Oct 30;124(2):503-6 PMID: 6093803
  137. The actions of pancreozymin in pancreas slices and the role of phospholipids in enzyme secretion.
    J Physiol. 1956 May 28;132(2):442-53 PMID: 13320409
  138. Failure of phosphatidic acid to translocate Ca2+ across phosphatidylcholine membranes.
    Nature. 1983 Oct 13-19;305(5935):637-8 PMID: 6684734
  139. Platelet-derived growth factor elicits cyclic AMP accumulation in Swiss 3T3 cells: role of prostaglandin production.
    Cell. 1983 Aug;34(1):265-72 PMID: 6192934
  140. Phosphatidylinositol 4,5-bisphosphate may represent the site of release of plasma membrane-bound calcium upon stimulation of human platelets.
    Biochem Biophys Res Commun. 1984 Apr 16;120(1):226-31 PMID: 6324792
  141. THE CHROMATOGRAPHIC SEPARATION OF POLYPHOSPHOINOSITIDES AND STUDIES ON THEIR TURNOVER IN VARIOUS TISSUES.
    Biochim Biophys Acta. 1964 Oct 2;84:550-62 PMID: 14250493
  142. Brain diphosphoninositide, a new phosphatide having inositol metadiphosphate as a constituent.
    J Biol Chem. 1949 Feb;177(2):505-19 PMID: 18110428
  143. 5-HT-stimulated arachidonic acid release from labeled phosphatidylinositol in blowfly salivary glands.
    Am J Physiol. 1982 Nov;243(5):C222-6 PMID: 6814261
  144. Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids.
    Biochem J. 1961 Apr;79:193-200 PMID: 13752435
  145. Phospholipid-sensitive Ca2+-dependent protein kinase: a major protein phosphorylation system.
    Mol Cell Endocrinol. 1984 May;35(2-3):65-73 PMID: 6203790
  146. Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices.
    Biochim Biophys Acta. 1955 Sep;18(1):102-10 PMID: 13260248
  147. The site of diphosphoinositide synthesis in rat liver.
    Biochem Biophys Res Commun. 1965 Nov 22;21(4):333-8 PMID: 4286175
  148. Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands.
    Biochem J. 1983 Dec 15;216(3):633-40 PMID: 6320795
  149. Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets.
    Biochem J. 1984 Dec 15;224(3):933-40 PMID: 6525180
  150. Calcium-dependent activation of lymphocytes by ionophore, A23187, and a phorbol ester tumor promoter.
    J Cell Physiol. 1983 Jul;116(1):51-6 PMID: 6406522
  151. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands.
    Biochem J. 1982 Sep 15;206(3):587-95 PMID: 7150264
  152. The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.
    J Biol Chem. 1981 Jan 25;256(2):579-82 PMID: 7451460
  153. Further observations concerning the action of pituitary thyrotropin on the intermediate metabolism of sheep thyroid tissue in vitro.
    Endocrinology. 1960 Jun;66:851-9 PMID: 13855801
  154. Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli.
    Biochem J. 1984 Aug 1;221(3):803-11 PMID: 6148075
  155. Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices.
    Biochem Biophys Res Commun. 1984 Sep 17;123(2):703-9 PMID: 6593069
  156. Polyphosphoinositide turnover in rat mast cells stimulated by antigen: rapid and preferential breakdown of phosphatidylinositol 4-phosphate (DPI).
    Biochem Biophys Res Commun. 1984 Sep 28;123(3):875-81 PMID: 6091652
  157. A phorbol ester and A23187 act synergistically to release acetylcholine from the guinea pig ileum.
    FEBS Lett. 1984 Sep 17;175(1):165-9 PMID: 6434345
  158. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
    Science. 1983 Jul 15;221(4607):275-7 PMID: 6304883
  159. THE INCORPORATION OF 32P FROM TRIPHOSPHATE INTO POLYPHOSPHOINOSITIDES (GAMMA-32P)ADENOSINE AND PHOSPHATIDIC ACID IN ERYTHROCYTE MEMBRANES.
    Biochim Biophys Acta. 1964 Oct 2;84:563-75 PMID: 14250494
  160. Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.
    J Biol Chem. 1981 Jul 25;256(14):7146-9 PMID: 7251589
  161. Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor.
    Biochem J. 1984 Aug 15;222(1):195-201 PMID: 6089758
  162. Phorbol 12-myristate 13-acetate, ionomycin or ouabain, and raised extracellular magnesium induce proliferation of chicken heart mesenchymal cells.
    Proc Natl Acad Sci U S A. 1984 Oct;81(20):6418-21 PMID: 6333683
  163. The enzymatic synthesis of inositol monophosphatide.
    J Biol Chem. 1960 May;235:1303-11 PMID: 14431034
  164. Ca2+ ionophores affect phosphoinositide metabolism differently than thyrotropin-releasing hormone in GH3 pituitary cells.
    J Biol Chem. 1984 Aug 10;259(15):9514-9 PMID: 6086636
  165. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
    Biochem J. 1983 May 15;212(2):473-82 PMID: 6309146
  166. Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells.
    Mol Pharmacol. 1984 Sep;26(2):149-55 PMID: 6090879
  167. Ca(phosphatidate)2 can traverse liposomal bilayers.
    Life Sci. 1984 Sep 24;35(13):1395-9 PMID: 6482661
  168. Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle.
    Biochem J. 1980 Dec 15;192(3):783-91 PMID: 6263262
  169. Production of phosphoinositide-derived messengers.
    Cell. 1984 Jul;37(3):701-3 PMID: 6331677
  170. Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum.
    Cell Calcium. 1984 Jun;5(3):191-203 PMID: 6090026
  171. Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.
    J Biol Chem. 1984 Aug 25;259(16):10201-7 PMID: 6088487
  172. Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.
    J Biol Chem. 1984 May 10;259(9):5574-84 PMID: 6325442
  173. Intracellular phospholipases A.
    Biochim Biophys Acta. 1980 Sep 30;604(2):191-246 PMID: 6252969
  174. Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.
    J Biol Chem. 1983 Oct 10;258(19):11442-5 PMID: 6311812
  175. Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas.
    Biochem J. 1983 May 15;212(2):483-8 PMID: 6309147
  176. Epidermal growth factor induces electrically silent Na+ influx in human fibroblasts.
    J Biol Chem. 1982 Jul 25;257(14):8502-6 PMID: 6979542
  177. Subcellular site and mechanism of vasopressin-stimulated hydrolysis of phosphoinositides in rat hepatocytes.
    J Biol Chem. 1984 Jun 25;259(12):7666-72 PMID: 6330070
  178. Release and metabolism of arachidonic acid in human neutrophils.
    J Biol Chem. 1981 Jul 25;256(14):7228-34 PMID: 6788763
  179. Structural and chemical specificity of diacylglycerols for protein kinase C activation.
    Biochem Biophys Res Commun. 1984 Nov 30;125(1):163-9 PMID: 6239621
  180. Phosphoinositide interconversion in thrombin-stimulated human platelets.
    J Biol Chem. 1985 Jan 25;260(2):1046-51 PMID: 2981829
  181. Insulin secretion: combined effects of phorbol ester and A23187.
    Biochem Biophys Res Commun. 1983 Dec 16;117(2):448-55 PMID: 6229253
  182. Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate.
    Biochem J. 1984 Oct 1;223(1):229-36 PMID: 6333869
  183. Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat.
    J Neurochem. 1981 Jun;36(6):1947-51 PMID: 6264039
  184. Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function.
    Biochem Soc Trans. 1981 Oct;9(5):377-9 PMID: 6269920
  185. Eicosanoids: prostaglandins, thromboxanes, leukotrienes, and other derivatives of carbon-20 unsaturated fatty acids.
    J Neurochem. 1982 Jan;38(1):1-14 PMID: 6286875
  186. A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.
    J Biol Chem. 1983 Feb 10;258(3):2010-3 PMID: 6218169
  187. Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.
    J Biol Chem. 1983 Jun 10;258(11):6701-4 PMID: 6406488
  188. The roles of calcium and cyclic AMP in cell proliferation.
    Ann N Y Acad Sci. 1980;339:216-40 PMID: 6249140
  189. Phorbol ester stimulation of Na influx and Na-K pump activity in Swiss 3T3 cells.
    Biochem Biophys Res Commun. 1981 May 15;100(1):433-41 PMID: 6266407
  190. Identification of a calcium- and phospholipid- dependent phorbol ester binding activity in the soluble fraction of mouse tissues.
    Biochem Biophys Res Commun. 1983 Feb 28;111(1):340-5 PMID: 6830598
  191. The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor.
    Biochim Biophys Acta. 1984 Apr 18;793(2):269-77 PMID: 6424715
  192. Aldosterone secretion: effect of phorbol ester and A23187.
    Biochem Biophys Res Commun. 1983 Oct 31;116(2):555-62 PMID: 6418161
  193. Complete fractionation of brain cephalin; isolation from it of phosphatidyl serine, phosphatidyl ethanolamine, and diphosphoinositide.
    J Biol Chem. 1949 Feb;177(2):497-504 PMID: 18110427
  194. Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
    J Biol Chem. 1982 Nov 10;257(21):12705-8 PMID: 6290478
  195. Relative degradation of different molecular species of phosphatidylcholine in thrombin-stimulated human platelets.
    J Biol Chem. 1984 Aug 10;259(15):9369-73 PMID: 6746652
  196. Phosphatidylinositol kinase and diphosphoinositide kinase of rat kidney cortex: properties and subcellular localization.
    Biochem J. 1976 Oct 15;160(1):97-105 PMID: 12747
  197. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in hepatocytes by vasopressin.
    J Biol Chem. 1983 Mar 10;258(5):2770-3 PMID: 6298203
  198. Reduced brain inositol in lithium-treated rats.
    Nat New Biol. 1971 Oct 27;233(43):267-8 PMID: 5288124
  199. Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function.
    Cell Calcium. 1982 Oct;3(4-5):467-502 PMID: 6297743
  200. Calcium and lymphocyte activation.
    Cell Immunol. 1976 Jul;25(1):74-89 PMID: 183895
  201. Mechanism of photoinactivation and re-activation in the bioluminescence system of the ctenophore Mnemiopsis.
    Biochem J. 1984 Jul 1;221(1):269-72 PMID: 6147135
  202. Possible regulation of phospholipase C activity in human platelets by phosphatidylinositol 4',5'-bisphosphate.
    Arch Biochem Biophys. 1984 Jan;228(1):299-308 PMID: 6320736
  203. Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation.
    Proc Natl Acad Sci U S A. 1983 Feb;80(4):965-8 PMID: 6341992
  204. Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.
    Proc Natl Acad Sci U S A. 1984 Dec;81(24):7713-7 PMID: 6151178
  205. Proposed mechanism of cholinergic action in smooth muscle.
    Nature. 1980 Mar 27;284(5754):344-5 PMID: 6767193
  206. Metabolism of inositol phosphates in parotid cells: implications for the pathway of the phosphoinositide effect and for the possible messenger role of inositol trisphosphate.
    Life Sci. 1984 Apr 2;34(14):1347-55 PMID: 6323902
  207. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
    Nature. 1983 Jul 7-13;304(5921):35-9 PMID: 6306471
  208. Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.
    J Biol Chem. 1981 Dec 10;256(23):12329-35 PMID: 6795201
  209. Inositol 1,4,5-trisphosphate may be a signal for f-Met-Leu-Phe-induced intracellular Ca mobilisation in human leucocytes (HL-60 cells).
    FEBS Lett. 1984 Oct 15;176(1):193-6 PMID: 6333356
  210. A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes.
    Biochem J. 1977 May 15;164(2):389-97 PMID: 328012
  211. The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation.
    Biochem J. 1984 Nov 15;224(1):129-36 PMID: 6439191
  212. Biochemical mechanisms in the phosphatidylinositol effect.
    Life Sci. 1983 May 2;32(18):2047-54 PMID: 6843282
  213. Lithium-induced accumulation of inositol 1-phosphate during cholecystokinin octapeptide- and acetylcholine-stimulated phosphatidylinositol breakdown in dispersed mouse pancreas acinar cells.
    J Biol Chem. 1984 Apr 10;259(7):4346-52 PMID: 6323467
  214. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.
    Proc Natl Acad Sci U S A. 1984 Dec;81(24):7797-801 PMID: 6393128
  215. Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.
    Nature. 1984 Jun 7-13;309(5968):562-4 PMID: 6328320
  216. Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombin.
    Biochem Biophys Res Commun. 1980 Nov 17;97(1):309-17 PMID: 6450593
  217. Acetylcholine stimulation of the phosphodiesteratic cleavage of guinea pig brain phosphoinositides.
    Life Sci. 1968 Apr 15;7(8):363-8 PMID: 4296977
  218. Competitive inhibition by diacylglycerol of specific phorbol ester binding.
    Proc Natl Acad Sci U S A. 1984 Jan;81(2):607-10 PMID: 6320198
  219. Autoradiographic localization of the acetylcholine-stimulated synthesis of phosphatidylinositol in the superior cervical ganglion.
    Proc Natl Acad Sci U S A. 1965 Jun;53(6):1369-76 PMID: 4285997
  220. THE BIOSYNTHESIS OF PROSTAGLANDINS.
    Biochim Biophys Acta. 1964 Jul 15;90:204-7 PMID: 14201167
  221. Activation of human platelet phospholipase C by ionophore A23187 is totally dependent upon cyclo-oxygenase products and ADP.
    Biochem J. 1984 Aug 15;222(1):103-10 PMID: 6433894
  222. An early alteration in the phospholipid metabolism of lymphocytes by phytohemagglutinin.
    Proc Natl Acad Sci U S A. 1968 Aug;60(4):1396-402 PMID: 4299946
  223. Ligand-stimulated inositol lipid metabolism in the liver: relationship to receptor function.
    Cell Calcium. 1982 Oct;3(4-5):399-411 PMID: 6297741
  224. The role of protein kinase C in cell surface signal transduction and tumour promotion.
    Nature. 1984 Apr 19-25;308(5961):693-8 PMID: 6232463
  225. Phosphoinositide synthesis and Ca2+ gating in blowfly salivary glands exposed to 5-hydroxytryptamine.
    Biochem J. 1984 Sep 1;222(2):327-34 PMID: 6089767
  226. Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
    J Biol Chem. 1984 Jun 10;259(11):7056-60 PMID: 6144681
  227. Acetylcholine promotes the synthesis of prostaglandin E in mouse pancreas.
    FEBS Lett. 1980 Aug 11;117(1):131-3 PMID: 7409158
  228. Synergistic activation of rat hepatocyte glycogen phosphorylase by A23187 and phorbol ester.
    Biochem Biophys Res Commun. 1984 Feb 29;119(1):88-94 PMID: 6422939
  229. Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus.
    Eur J Pharmacol. 1983 Sep 30;93(3-4):245-53 PMID: 6196211
  230. Accumulation of the inositol phosphates in thrombin-stimulated, washed rabbit platelets in the presence of lithium.
    Biochem J. 1984 Dec 1;224(2):399-405 PMID: 6517858
  231. Positional distribution and turnover of fatty acids in phosphatidic acid, phosphinositides, phosphatidylcholine and phosphatidylethanolamine in rat brain in vivo.
    Biochim Biophys Acta. 1972 Aug 11;270(4):489-503 PMID: 4340991
  232. Cyclic GMP metabolism and involvement in biological regulation.
    Annu Rev Biochem. 1977;46:823-96 PMID: 20041
  233. The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high-affinity binding sites of cultured hamster cells.
    Biochem J. 1983 Nov 15;216(2):299-308 PMID: 6661198
  234. Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.
    J Biol Chem. 1980 Nov 10;255 (21):10227-31 PMID: 7430120
  235. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
    Biochem J. 1983 Jun 15;212(3):849-58 PMID: 6309155
  236. Serum rapidly mobilizes calcium from an intracellular pool in quiescent fibroblastic cells.
    Biochem Biophys Res Commun. 1983 Jul 18;114(1):240-7 PMID: 6882425
  237. Stimulation of inositol trisphosphate accumulation and amylase secretion by caerulein in pancreatic acini.
    J Pharmacol Exp Ther. 1984 Dec;231(3):623-7 PMID: 6209388
  238. Studies on the enzymic hydrolysis of monophosphoinositide by phospholipase preparations from P. notatum and ox pancreas.
    Biochim Biophys Acta. 1959 May;33(1):68-77 PMID: 13651185
  239. Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum.
    Biochim Biophys Acta. 1981 Nov 6;648(2):113-9 PMID: 6118177
  240. Inositol trisphosphate activates pyruvate dehydrogenase in isolated fat cells.
    FEBS Lett. 1984 Oct 29;176(2):411-3 PMID: 6436058
  241. Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate.
    Nature. 1984 Sep 13-19;311(5982):157-60 PMID: 6472473
  242. Hormonal regulation of phosphatidylinositol breakdown.
    Life Sci. 1983 May 2;32(18):2055-67 PMID: 6302422
  243. The second messenger linking receptor activation to internal Ca release in liver.
    Nature. 1984 May 3-9;309(5963):63-6 PMID: 6325926
  244. Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Studies with lithium.
    Mol Pharmacol. 1984 Mar;25(2):201-8 PMID: 6321943
  245. Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells.
    Biochemistry. 1981 Oct 13;20(21):6280-6 PMID: 6272837
  246. Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum.
    Biochem J. 1976 Mar 15;154(3):653-7 PMID: 182125
  247. Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM.
    Biochim Biophys Acta. 1983 Dec 20;754(3):305-14 PMID: 6317043
  248. Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
    J Clin Invest. 1977 Jul;60(1):1-6 PMID: 874074
  249. Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour.
    Biochem J. 1984 Apr 15;219(2):471-80 PMID: 6331389
  250. Effects of carbachol and pancreozymin (cholecystokinin-octapeptide) on polyphosphoinositide metabolism in the rat pancreas in vitro.
    Biochem J. 1984 Jan 1;217(1):281-7 PMID: 6199018
  251. Hormone-receptor--adenylate cyclase interactions.
    FEBS Lett. 1979 May 15;101(2):213-9 PMID: 376346
  252. Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents. I. Effects of different aggregating agents.
    Biochem Biophys Res Commun. 1977 Jul 25;77(2):714-22 PMID: 332167
  253. Phosphoinositide metabolism in the retina: localization to horizontal cells and regulation by light and divalent cations.
    J Neurochem. 1983 Sep;41(3):764-71 PMID: 6308171
  254. The relationship between phosphatidylinositol metabolism and mobilization of intracellular calcium elicited by alpha1-adrenergic receptor stimulation in BC3H-1 muscle cells.
    Mol Pharmacol. 1984 Nov;26(3):405-13 PMID: 6092893
  255. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.
    Proc Natl Acad Sci U S A. 1983 Jul;80(14):4208-12 PMID: 6308606
  256. Phosphatidic acid metabolism and active transport of sodium.
    Fed Proc. 1963 Jan-Feb;22:8-18 PMID: 13961251
  257. THE POSITIONAL DISTRIBUTION OF THE FATTY ACIDS IN PHOSPHATIDYL INOSITOL.
    Biochim Biophys Acta. 1964 Aug 5;84:458-60 PMID: 14230820
  258. Secretogogue-stimulated phosphatidylinositol breakdown in the exocrine pancreas liberates arachidonic acid, stearic acid, and glycerol by sequential actions of phospholipase C and diglyceride lipase.
    J Biol Chem. 1984 Dec 10;259(23):14418-25 PMID: 6438097
  259. A rapid stimulation of phosphatidylinositol metabolism in rabbit leukocytes by pseudomonal leukocidin.
    FEBS Lett. 1983 Jun 27;157(1):46-50 PMID: 6862019
  260. Direct stimulation of phosphatidylinositol degradation by addition of vasopressin to purified rat liver plasma membranes.
    Endocrinology. 1982 Jul;111(1):341-3 PMID: 7084119
  261. Acetylcholine increases the level of diglyceride in mouse pancreas.
    Biochem Biophys Res Commun. 1974 Jun 4;58(3):714-8 PMID: 4836273
  262. Phosphoinositide breakdown in isolated rat parotid membranes. Stimulation by cholinergic and alpha-adrenergic agonists.
    FEBS Lett. 1984 Dec 10;178(2):278-82 PMID: 6096168
  263. Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes.
    Nature. 1985 Jan 10-18;313(5998):141-3 PMID: 2578219
  264. Serum, bradykinin and vasopressin stimulate release of inositol phosphates from human fibroblasts.
    Biochem Biophys Res Commun. 1984 Sep 17;123(2):663-70 PMID: 6435618
  265. Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide.
    J Biol Chem. 1961 Jan;236:54-60 PMID: 13707646
  266. Phospholipid metabolism of 3T3 mouse fibroblasts after serum stimulation and through the G1 and S cell cycle phases : incorporation and disappearance of 32P.
    Biochimie. 1978;60(11-12):1307-13 PMID: 753380
  267. The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.
    J Biol Chem. 1981 May 25;256(10):5037-40 PMID: 6785276
  268. Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices.
    J Biol Chem. 1953 Aug;203(2):967-77 PMID: 13084667
  269. Activation of plasma membrane phosphatidylinositol turnover by hormones.
    Vitam Horm. 1984;41:117-60 PMID: 6397909
  270. Molecular actions of angiotensin.
    Biochem Pharmacol. 1981 Oct;30(20):2745-51 PMID: 6274350
  271. Stimulation of Na influx, Na-K pump activity and DNA synthesis in quiescent cultured cells.
    Adv Enzyme Regul. 1980;19:61-85 PMID: 7337035
  272. Intracellular Ca2+ and phorbol esters synergistically inhibit internalization of epidermal growth factor in pancreatic acini.
    Biochem J. 1984 Nov 1;223(3):893-900 PMID: 6095811
  273. Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells.
    Biochem J. 1982 Sep 15;206(3):555-60 PMID: 6184051
  274. Neurotransmitter receptors mediate cyclic GMP formation by involvement of arachidonic acid and lipoxygenase.
    Proc Natl Acad Sci U S A. 1984 Jun;81(12):3905-9 PMID: 6328532
  275. Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle.
    Biochem J. 1984 Oct 15;223(2):527-31 PMID: 6093776
  276. Phosphoinositides and protein secretion in pancreas slices.
    J Biol Chem. 1958 Oct;233(4):805-10 PMID: 13587496
  277. myo-Inositol 1,4,5-trisphosphate stimulates protein phosphorylation in saponin-permeabilized human platelets.
    Proc Natl Acad Sci U S A. 1984 Dec;81(23):7431-5 PMID: 6438636
  278. Degradation of different molecular species of phosphatidylinositol in thrombin-stimulated human platelets.
    J Biol Chem. 1983 May 10;258(9):5337-9 PMID: 6853517
  279. Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils. Relationship to calcium mobilization, aggregation and superoxide radical generation.
    Biochim Biophys Acta. 1983 Jun 2;762(3):420-8 PMID: 6303442
  280. 1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets.
    Biochem Biophys Res Commun. 1984 May 31;121(1):386-91 PMID: 6732815
  281. Differential activation of phosphatidylinositol deacylation and a pathway via diphosphoinositide in macrophages responding to zymosan and ionophore A23187.
    J Biol Chem. 1984 Mar 10;259(5):3111-6 PMID: 6321496
  282. Diglyceride/monoglyceride lipases pathway is not essential for arachidonate release in thrombin-activated human platelets.
    Biochem Biophys Res Commun. 1983 May 31;113(1):241-7 PMID: 6305350
  283. On the mechanism by which hormones induce the release of Ca2+ from mitochondria in the liver cell.
    Biochem J. 1982 Jul 15;206(1):121-9 PMID: 6812571
  284. Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.
    J Biol Chem. 1984 Nov 25;259(22):13777-82 PMID: 6334080
  285. Inositol trisphosphate and diacylglycerol as second messengers.
    Biochem J. 1984 Jun 1;220(2):345-60 PMID: 6146314
  286. Effects of acetylcholine on phospholipides in the pancreas.
    J Biol Chem. 1954 Aug;209(2):549-58 PMID: 13192107
  287. Norepinephrine causes alpha 1-adrenergic receptor-mediated decrease of phosphatidylinositol in isolated rat liver plasma membranes supplemented with cytosol.
    J Biol Chem. 1983 Feb 25;258(4):2087-90 PMID: 6296125
  288. Arachidonic acid mobilizes calcium and stimulates prolactin secretion from GH3 cells.
    Am J Physiol. 1984 May;246(5 Pt 1):E458-62 PMID: 6426317
  289. Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate.
    J Biol Chem. 1983 Jan 25;258(2):764-9 PMID: 6822511
  290. The properties and subcellular distribution of phosphatidylinositol kinase in mammalian tissues.
    Biochim Biophys Acta. 1969 Jan 7;171(1):75-88 PMID: 4303199
  291. Phosphate incorporation in brain phosphionositides.
    J Biol Chem. 1962 Jan;237:49-52 PMID: 13873263
  292. Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery.
    Biochem Biophys Res Commun. 1984 Apr 30;120(2):481-5 PMID: 6610416
  293. Calcium messenger system: an integrated view.
    Physiol Rev. 1984 Jul;64(3):938-84 PMID: 6330778
  294. Properties of phosphatidylinositol kinase activities in rabbit erythrocyte membranes.
    Arch Biochem Biophys. 1983 Apr 1;222(1):170-8 PMID: 6301380
  295. Studies on enzymes related to diacylglycerol production in activated platelets. II. Subcellular distribution, enzymatic properties and positional specificity of diacylglycerol- and monoacylglycerol-lipases.
    Biochim Biophys Acta. 1984 Nov 14;796(2):169-77 PMID: 6498209
  296. Prostaglandin synthesis linked to phosphatidylinositol turnover in isolated rat glomeruli.
    Biochim Biophys Acta. 1984 Jul 6;794(2):206-17 PMID: 6428457
  297. Rapid polyphosphoinositide decrease is an early event in the steroidogenic response of bovine adrenocortical fasciculata cells to angiotensin II.
    Biochem Biophys Res Commun. 1984 Oct 30;124(2):393-9 PMID: 6093798
  298. Biosynthesis and biological actions of prostaglandins and thromboxanes.
    Arch Biochem Biophys. 1982 Apr 1;214(2):431-45 PMID: 6284025
  299. Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets.
    J Biol Chem. 1982 Jul 10;257(13):7314-7 PMID: 7045103
  300. Possible role of lysosomal phospholidpases in inducing tissue prostaglandin synthesis.
    Adv Prostaglandin Thromboxane Res. 1978;3:47-54 PMID: 350022
  301. Preferential utilization of endogenous arachidonate by cyclo-oxygenase in incubations of human platelets.
    FEBS Lett. 1983 Jun 27;157(1):173-8 PMID: 6407867
  302. Is phosphatidic acid a calcium ionophore under neurohumoral control?
    Nature. 1980 Mar 27;284(5754):345-7 PMID: 6244502
  303. Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.
    J Biol Chem. 1984 Sep 10;259(17):10675-81 PMID: 6236219
  304. Phospholipide turnover in microsomal membranes of the pancreas during enzyme secretion.
    J Biophys Biochem Cytol. 1959 Oct;6:207-14 PMID: 14436835
  305. Acetylcholine-stimulated phosphodiesteratic cleavage of phosphoinositides: hypothetical role in membrane depolarization.
    Ann N Y Acad Sci. 1969 Oct 17;165(2):743-54 PMID: 4310384
  306. Inositol lipid metabolism in the responses of stimulated platelets.
    Cell Calcium. 1982 Oct;3(4-5):311-22 PMID: 6760975
  307. The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions.
    Philos Trans R Soc Lond B Biol Sci. 1981 Dec 18;296(1080):123-38 PMID: 6121338
  308. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
    Nature. 1984 Feb 9-15;307(5951):521-7 PMID: 6320011
  309. Calcium signals and phospholipid methylation in eukaryotic cells.
    Biochem J. 1984 Aug 1;221(3):675-84 PMID: 6477493
  310. How is the level of free arachidonic acid controlled in mammalian cells?
    Biochem J. 1982 Apr 15;204(1):3-16 PMID: 6810878
  311. myo-Inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors.
    Nature. 1984 Sep 13-19;311(5982):160-3 PMID: 6472474
  312. Receptor-mediated metabolism of the phosphoinositides and phosphatidic acid in rat lacrimal acinar cells.
    Biochem J. 1984 Feb 15;218(1):187-95 PMID: 6324749
Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01870664
Published
1986-00-00
Pages
193-210
Language
English
Region
United States
NLM ID
0211301
Subset
IM
Grants
NIDA NIH HHS · DA03699 · United States
NHLBI NIH HHS · HL16318 · United States
External Links
PubMed source DOI: 10.1007/BF01870664 View journal details
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