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PMID: 2989411 Published · ppublish English Journal Article

Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells.

The Journal of experimental medicine ·Vol. 162 ·No. 1 ·1985-07-01 ·Pages 363-8

Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ

Abstract

Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the aberrant size of the IL-2 receptors on HUT 102B2 cells, (b) did not respond to exogenous IL-2 with augmented proliferation, and (c) expressed low affinity but not high affinity receptors for IL-2.

MeSH Terms
Animals DNA/genetics Genetic Vectors Humans Interleukin-2/immunology L Cells/immunology Mice Receptors, Immunologic/biosynthesis,genetics,metabolism Receptors, Interleukin-2 Simian virus 40/genetics Transfection
Chemicals
Interleukin-2 Receptors, Immunologic Receptors, Interleukin-2 DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Greene W C
Robb R J
Svetlik P B
Rusk C M
Depper J M
Leonard W J
References (18)
18 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.1.363
Published
1985-07-01
Pages
363-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187706
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.162.1.363 PMC Full Text View journal details
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