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PMID: 28725219 Published · epublish English Journal Article

Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity.

Frontiers in microbiology ·Vol. 8 ·2017-00-00 ·Pages 1243

Yang L, Liu S, Ding J, Dai R, He C, Xu K, Honaker CF, Zhang Y, Siegel P, Meng H

Abstract

To explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity.

Keywords
antibody titers chicken co-microevolution gut microbiota host-microbe interactions humoral immunity
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Yang Lingyu
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
Liu Shuyun
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
Ding Jinmei
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
Dai Ronghua
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
He Chuan
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
Xu Ke
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
Honaker Christa F
Department of Animal and Poultry Sciences, Virginia TechBlacksburg, VA, United States.
Zhang Yan
Carilion ClinicRoanoke, VA, United States.
Siegel Paul
Department of Animal and Poultry Sciences, Virginia TechBlacksburg, VA, United States.
Meng He
Shanghai Key Laboratory of Veterinary Biotechnology, Department of Animal Science, School of Agriculture and Biology, Shanghai Jiao Tong UniversityShanghai, China.
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Article Info
Journal
Frontiers in microbiology
Abbr.
Front Microbiol
ISSN
1664-302X
DOI
10.3389/fmicb.2017.01243
Published
2017-00-00
Epub
2017-00-04
Pages
1243
Language
English
Region
Switzerland
NLM ID
101548977
PMCID
PMC5495859
Grants
NIAAA NIH HHS · R01 AA010090 · United States
External Links
PubMed source DOI: 10.3389/fmicb.2017.01243 PMC Full Text View journal details
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