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PMID: 20826446 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Epithelial crosstalk at the microbiota-mucosal interface.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 108 Suppl 1 ·2011-03-15 ·Pages 4607-14

Wells JM, Rossi O, Meijerink M, van Baarlen P

Abstract

This article provides an overview of how intestinal epithelial cells (IEC) recognize commensals and how they maintain host-bacterial symbiosis. Endocrine, goblet cells, and enterocytes of the intestinal epithelium express a range of pattern recognition receptors (PRR) to sense the presence of microbes. The best characterized are the Toll-like receptors (TLR) and nucleotide oligomerization domain-like receptors (NLR), which play a key role in pathogen recognition and the induction of innate effectors and inflammation. Several adaptations of PRR signaling have evolved in the gut to avoid uncontrolled and potentially destructive inflammatory responses toward the resident microbiota. PRR signaling in IEC serve to maintain the barrier functions of the epithelium, including the production of secretory IgA (sIgA). Additionally, IECs play a cardinal role in setting the immunosuppressive tone of the mucosa to inhibit overreaction against innocuous luminal antigens. This includes regulation of dendritic cells (DC), macrophage and lymphocyte functions by epithelial secreted cytokines. These immune mechanisms depend heavily on IEC recognition of microbes and are consistent with several studies in knockout mice that demonstrate TLR signaling in the epithelium has a profoundly beneficial role in maintaining homeostasis.

MeSH Terms
Animals Humans Immune Tolerance/immunology Immunoglobulin A, Secretory/metabolism Intestinal Mucosa/immunology,microbiology Metagenome Mice Receptors, Pattern Recognition/metabolism Signal Transduction Symbiosis
Chemicals
Immunoglobulin A, Secretory Receptors, Pattern Recognition
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wells Jerry M
Host-Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands. jerry.wells@wur.nl
Rossi Oriana
Meijerink Marjolein
van Baarlen Peter
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1000092107
Email
jerry.wells@wur.nl
Published
2011-03-15
Epub
2010-00-08
Pages
4607-14
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3063605
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.1000092107 PMC Full Text View journal details
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