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PMID: 28323260 Published · ppublish English Journal Article Review

Mechanisms and consequences of Jak-STAT signaling in the immune system.

Nature immunology ·Vol. 18 ·No. 4 ·2017-00-22 ·Pages 374-384

Villarino AV, Kanno Y, O'Shea JJ

Abstract

Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs. Here we review recent advances in Jak-STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent TFs.

MeSH Terms
Animals Gene Expression Regulation Genome-Wide Association Study Humans Immune System/drug effects,immunology,metabolism Janus Kinases/genetics,metabolism Molecular Targeted Therapy Multigene Family Protein Binding STAT Transcription Factors/genetics,metabolism Signal Transduction/drug effects Translational Research, Biomedical
Chemicals
STAT Transcription Factors Janus Kinases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Villarino Alejandro V ORCID
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Kanno Yuka
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
O'Shea John J
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.3691
Published
2017-00-22
Pages
374-384
Language
English
Region
United States
NLM ID
100941354
Subset
IM
External Links
PubMed source DOI: 10.1038/ni.3691 View journal details
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