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PMID: 24362405 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of type I interferon responses.

Nature reviews. Immunology ·Vol. 14 ·No. 1 ·2014-01-00 ·Pages 36-49

Ivashkiv LB, Donlin LT

Abstract

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs). Host, pathogen and environmental factors regulate the responses of cells to this signalling pathway and thus calibrate host defences while limiting tissue damage and preventing autoimmunity. Here, we summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation. These regulatory mechanisms determine the biological outcomes of type I IFN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues.

MeSH Terms
Adaptive Immunity Animals Autoimmune Diseases/immunology Epigenesis, Genetic Gene Expression Regulation Humans Immunity, Innate Infections/immunology Interferon Type I/biosynthesis,genetics,immunology Mice Models, Immunological STAT Transcription Factors/immunology Signal Transduction
Chemicals
Interferon Type I STAT Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ivashkiv Lionel B
1] Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York 10021, USA. [2] Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA. [3] Department of Medicine, Weill Cornell Medical College, New York, New York 10065,USA.
Donlin Laura T
Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York 10021, USA.
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3581
Published
2014-01-00
Pages
36-49
Language
English
Region
England
NLM ID
101124169
PMCID
PMC4084561
Subset
IM
Grants
NIAMS NIH HHS · R01 AR046713 · United States
NIDCR NIH HHS · R01 DE019420 · United States
NIAID NIH HHS · R01 AI046712 · United States
NIAMS NIH HHS · K01 AR066063 · United States
NIAMS NIH HHS · R01 AR050401 · United States
NIAID NIH HHS · R01 AI044938 · United States
External Links
PubMed source DOI: 10.1038/nri3581 PMC Full Text View journal details
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