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PMID: 2792079 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells.

The EMBO journal ·Vol. 8 ·No. 7 ·1989-07-00 ·Pages 1987-91

Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico MG

Abstract

A novel human gene, encoding a 188 amino acid polypeptide that contains a region similar to that of the epidermal growth factor, has been isolated. The gene, expressed in undifferentiated human and mouse teratocarcinoma cells, is shut off after inducing the cells to differentiate by treatment with retinoic acid. Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Northern Cell Differentiation/drug effects Cell Line Cells, Cultured DNA, Neoplasm/genetics,isolation & purification Epidermal Growth Factor/genetics Genes Humans Mice Molecular Sequence Data Multigene Family Sequence Homology, Nucleic Acid Teratoma/genetics Transcription, Genetic Tretinoin/pharmacology
Chemicals
DNA, Neoplasm Tretinoin Epidermal Growth Factor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Ciccodicola A
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Dono R
Obici S
Simeone A
Zollo M
Persico M G
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1989-07-00
Pages
1987-91
Language
English
Region
England
NLM ID
8208664
PMCID
PMC401069
Subset
IM
Databases
GENBANK
X14253
External Links
PubMed source PMC Full Text View journal details
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