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PMID: 2690066 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 24 ·1989-12-00 ·Pages 10018-22

Strich R, Slater MR, Esposito RE

Abstract

Mutations in Saccharomyces cerevisiae have been identified that derepress early meiotic genes functioning in separable pathways required for normal meiotic development. The phenotypes of these ume (unscheduled meiotic gene expression) mutations suggest that their wild-type alleles encode negative regulators acting downstream of both the cell-type and nutritional controls of meiosis. These newly defined loci do not affect either general transcription or transcription of meiotic genes expressed later in meiosis and spore formation.

MeSH Terms
Gene Expression Regulation, Fungal Genes, Fungal Genes, Regulator Genetic Techniques Meiosis Mutation Plasmids RNA, Fungal/genetics,isolation & purification RNA, Messenger/genetics Saccharomyces cerevisiae/cytology,genetics,growth & development Spores, Fungal/physiology Transcription, Genetic
Chemicals
RNA, Fungal RNA, Messenger
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Strich R
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637.
Slater M R
Esposito R E
References (24)
24 references, click to expand
  1. Regulation of mating and meiosis in yeast by the mating-type region.
    Genetics. 1976 Feb;82(2):187-206 PMID: 770230
  2. A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiae.
    Mol Cell Biol. 1989 May;9(5):2142-52 PMID: 2664470
  3. Recombination and chromosome segregation during the single division meiosis in SPO12-1 and SPO13-1 diploids.
    Genetics. 1980 Nov;96(3):589-611 PMID: 7021312
  4. Control of cell type in yeast by the mating type locus. The alpha 1-alpha 2 hypothesis.
    J Mol Biol. 1981 Apr 15;147(3):357-72 PMID: 7031257
  5. Properties of a Saccharomyces cerevisiae mtDNA segment conferring high-frequency yeast transformation.
    Proc Natl Acad Sci U S A. 1982 Mar;79(5):1578-82 PMID: 7041124
  6. A new mapping method employing a meiotic rec-mutant of yeast.
    Genetics. 1982 Mar;100(3):387-412 PMID: 6749597
  7. Transformation of intact yeast cells treated with alkali cations.
    J Bacteriol. 1983 Jan;153(1):163-8 PMID: 6336730
  8. Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase.
    Cell. 1983 Feb;32(2):417-23 PMID: 6297794
  9. RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.
    Proc Natl Acad Sci U S A. 1983 May;80(9):2432-6 PMID: 6189122
  10. Isolation of DNA sequences preferentially expressed during sporulation in Saccharomyces cerevisiae.
    Mol Cell Biol. 1984 Jan;4(1):142-50 PMID: 6366508
  11. Yeast promoters: positive and negative elements.
    Cell. 1984 Apr;36(4):799-800 PMID: 6368004
  12. In yeast, RAS proteins are controlling elements of adenylate cyclase.
    Cell. 1985 Jan;40(1):27-36 PMID: 2981630
  13. Identification and comparison of two sequence elements that confer cell-type specific transcription in yeast.
    Nature. 1985 Apr 18-24;314(6012):598-603 PMID: 3887184
  14. RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation.
    Proc Natl Acad Sci U S A. 1985 Jun;82(11):3785-9 PMID: 3889915
  15. The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.
    Cell. 1985 Dec;43(2 Pt 1):483-92 PMID: 3907857
  16. Activation of meiosis and sporulation by repression of the RME1 product in yeast.
    Nature. 1986 Feb 27-Mar 5;319(6056):738-42 PMID: 3513021
  17. RAS genes and growth control in Saccharomyces cerevisiae.
    J Bacteriol. 1986 May;166(2):364-7 PMID: 3516972
  18. Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae.
    Mol Cell Biol. 1986 Jul;6(7):2443-51 PMID: 3023934
  19. Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast.
    Cell. 1987 Feb 27;48(4):579-87 PMID: 3028642
  20. Developmental regulation of SPO13, a gene required for separation of homologous chromosomes at meiosis I.
    Mol Cell Biol. 1987 Apr;7(4):1425-35 PMID: 3299047
  21. Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae.
    Mol Cell Biol. 1987 May;7(5):1906-16 PMID: 3037338
  22. Isolation, DNA sequence, and regulation of a meiosis-specific eukaryotic recombination gene.
    Proc Natl Acad Sci U S A. 1987 Nov;84(22):8035-9 PMID: 3317399
  23. IME1, a positive regulator gene of meiosis in S. cerevisiae.
    Cell. 1988 Mar 25;52(6):853-62 PMID: 3280136
  24. Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2199-203 PMID: 6264467
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.24.10018
Published
1989-12-00
Pages
10018-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC522385
Subset
IM
Grants
NCI NIH HHS · CA09273 · United States
NIGMS NIH HHS · GM29182 · United States
NICHD NIH HHS · HD19252 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.24.10018 PMC Full Text View journal details
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