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PMID: 265536 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 2 ·1977-02-00 ·Pages 725-9

Goldstein AL, Low TL, McAdoo M, McClure J, Thurman GB, Rossio J, Lai CY, Chang D, Wang SS, Harvey C, Ramel AH, Meienhofer J

Abstract

The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Animals Biological Assay Cattle Chymotrypsin Peptide Fragments/analysis Thermolysin Thymosin/immunology,isolation & purification Thymus Gland Thymus Hormones/immunology Trypsin
Chemicals
Amino Acids Peptide Fragments Thymus Hormones Thymosin Chymotrypsin Trypsin Thermolysin
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Goldstein A L
Low T L
McAdoo M
McClure J
Thurman G B
Rossio J
Lai C Y
Chang D
Wang S S
Harvey C
Ramel A H
Meienhofer J
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.2.725
Published
1977-02-00
Pages
725-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392366
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.2.725 PMC Full Text View journal details
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