Immunotherapy of the Dunning leukaemia with thymic extracts.

British journal of cancer ·Vol. 28 ·No. 4 ·1973-10-00 ·Pages 288-92

Khaw BA, Rule AH

Abstract

Injections of thymic extract (TE), TE primed lymphocytes or normal lymph node cells were effective in bringing about total remission of the Dunning leukaemia in inbred Fisher CD rats. Survival greater than 365 days occurred in 10-80% of the various treated groups whereas untreated leukaemic rats, or leukaemic rats treated with spleen "mock thymus extract" or bovine serum albumin, died within an average of 10-17 days. Administration of antilymphocyte serum into leukaemic rats enhanced their death rate. Stimulation of cell mediated immunity via the production of functional thymus stimulated lymphocytes is postulated as the mechanism by which tumour rejection occurred.

MeSH Terms

Animals Antilymphocyte Serum Glycoproteins/therapeutic use Immunity, Cellular Immunotherapy Leukemia/mortality Leukemia, Experimental/therapy Lymph Nodes Lymphocytes Rats Rats, Inbred Strains Remission, Spontaneous Serum Albumin, Bovine Spleen Thymus Extracts/therapeutic use Time Factors

Chemicals

Antilymphocyte Serum Glycoproteins Thymus Extracts Serum Albumin, Bovine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Khaw B A

Rule A H

References (13)

13 references, click to expand

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1973.150

Published

1973-10-00

Pages

288-92

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2008900

Subset

External Links

PubMed source DOI: 10.1038/bjc.1973.150 PMC Full Text View journal details

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Immunotherapy of the Dunning leukaemia with thymic extracts.

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