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PMID: 26471775 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

How leukocytes cross the vascular endothelium.

Nature reviews. Immunology ·Vol. 15 ·No. 11 ·2015-11-00 ·Pages 692-704

Vestweber D

Abstract

Immune responses depend on the ability of leukocytes to move from the circulation into tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow them to cross the barrier of the blood vessel wall. This process is regulated by a concerted action between endothelial cells and leukocytes, whereby endothelial cells activate leukocytes and direct them to extravasation sites, and leukocytes in turn instruct endothelial cells to open a path for transmigration. This Review focuses on recently described mechanisms that control and open exit routes for leukocytes through the endothelial barrier.

MeSH Terms
12E7 Antigen Animals Antigens, CD/physiology Cell Adhesion Molecules/physiology Cell Movement Endothelium, Vascular/physiology Humans Integrins/physiology Intercellular Adhesion Molecule-1/physiology Leukocytes/physiology
Chemicals
12E7 Antigen Antigens, CD CD99 protein, human Cell Adhesion Molecules Integrins Intercellular Adhesion Molecule-1
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Vestweber Dietmar
Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3908
Published
2015-11-00
Epub
2015-00-16
Pages
692-704
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri3908 View journal details
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