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PMID: 18723831 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Platelet chemokines in vascular disease.

Arteriosclerosis, thrombosis, and vascular biology ·Vol. 28 ·No. 11 ·2008-11-00 ·Pages 1920-7

Gleissner CA, von Hundelshausen P, Ley K

Abstract

Platelets are a rich source of different chemokines and express chemokine receptors. CXCL4 is highly abundant in platelets and involved in promoting monocyte arrest from rolling and monocyte differentiation to macrophages. CXCL4 can also associate with CCL5 and amplify its effect on monocytes. The megakaryocyte CXCL7 gene product is proteolytically cleaved into the strong neutrophil chemoattractant, NAP-2, which has also been implicated in repair cell homing to vascular lesions. Platelet adhesion can induce release of CCL2 and CXCL8 from endothelial cells. Conversely, the chemokines CCL17, CCL22, and CXCL12 made by other cells amplify platelet activation. Platelet chemokines enhance recruitment of various hematopoietic cells to the vascular wall, fostering processes such as neointima formation, atherosclerosis, and thrombosis, but also vessel repair and regeneration after vascular injury.

MeSH Terms
Animals Blood Platelets/immunology Cell Differentiation Chemokines/blood Chemotaxis Humans Platelet Activation Vascular Diseases/blood,immunology
Chemicals
Chemokines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Gleissner Christian A
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA.
von Hundelshausen Philipp
Ley Klaus
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Article Info
Journal
Arteriosclerosis, thrombosis, and vascular biology
Abbr.
Arterioscler Thromb Vasc Biol
ISSN
1524-4636
DOI
10.1161/ATVBAHA.108.169417
Published
2008-11-00
Epub
2008-00-21
Pages
1920-7
Language
English
Region
United States
NLM ID
9505803
PMCID
PMC2657037
Subset
IM
Grants
NHLBI NIH HHS · R01 HL058108-08 · United States
NHLBI NIH HHS · HL58108 · United States
NHLBI NIH HHS · P01 HL055798-070007 · United States
NHLBI NIH HHS · R01 HL058108 · United States
NHLBI NIH HHS · P01 HL055798 · United States
NHLBI NIH HHS · R01 HL058108-07 · United States
External Links
PubMed source DOI: 10.1161/ATVBAHA.108.169417 PMC Full Text View journal details
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