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PMID: 2547997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice.

Journal of virology ·Vol. 63 ·No. 9 ·1989-09-00 ·Pages 3810-21

Frankel WN, Stoye JP, Taylor BA, Coffin JM

Abstract

Forty-seven endogenous polytropic murine viruses (Pmv) were identified by examination of proviral-cellular DNA junction fragment segregation in recombinant inbred (RI) mice. Most Pmv loci were found in more than one of the seven RI progenitor strains analyzed, but only four were present in all strains. Chromosomal assignments for 41 Pmv loci were determined by comparing their RI strain distribution patterns with those of known genetic markers. Pmv loci were found dispersed throughout the genome, with chromosomes 1, 3, 4, 5, 7, 11, 12, 15, and 16 each carrying three or more proviruses. Linkage analysis in the AKXD RI set suggested that the gene encoding mink cell focus-forming virus resistance (Rcmfr) of DBA/2J mice is probably not a Pmv provirus. It was also deduced that no single, AKR/J-specific Pmv provirus is required as an env gene donor for thymomagenic mink cell focus-forming viruses. In addition, a Pmv provirus was very closely associated with the albino mutation on chromosome 7.

MeSH Terms
Animals Chromosome Mapping Female Leukemia Virus, Murine/genetics Male Mice Mice, Inbred Strains Mutation Proviruses/genetics Recombination, Genetic Sex Chromosomes Thymoma/etiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Frankel W N
Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Stoye J P
Taylor B A
Coffin J M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.9.3810-3821.1989
Published
1989-09-00
Pages
3810-21
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250974
Subset
IM
Grants
NCI NIH HHS · CA33093 · United States
NIGMS NIH HHS · GM18684 · United States
NCI NIH HHS · R3S-CA44385 · United States
External Links
PubMed source DOI: 10.1128/JVI.63.9.3810-3821.1989 PMC Full Text View journal details
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