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PMID: 2542969 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 11 ·1989-06-00 ·Pages 4316-20

Blackstone CD, Supattapone S, Snyder SH

Abstract

In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the response reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.

MeSH Terms
Animals Binding, Competitive Calcium Chloride/pharmacology Cerebellum/drug effects,physiology Egtazic Acid/pharmacology Glutamates/physiology In Vitro Techniques Inositol Phosphates/metabolism,physiology Kinetics Male Oxadiazoles/pharmacology Purkinje Cells/physiology Quisqualic Acid Rats Rats, Inbred Strains Receptors, Glutamate Receptors, Neurotransmitter/physiology Sugar Phosphates/physiology Synapses/physiology Synaptic Transmission
Chemicals
Glutamates Inositol Phosphates Oxadiazoles Receptors, Glutamate Receptors, Neurotransmitter Sugar Phosphates Egtazic Acid Quisqualic Acid Calcium Chloride
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Blackstone C D
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Supattapone S
Snyder S H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.11.4316
Published
1989-06-00
Pages
4316-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC287443
Subset
IM
Grants
NIDA NIH HHS · DA-00074 · United States
NIDA NIH HHS · DA-00266 · United States
NIMH NIH HHS · MH-18501 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.11.4316 PMC Full Text View journal details
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