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PMID: 2542569 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Structure of the Marek's disease virus BamHI-H gene family: genes of putative importance for tumor induction.

Journal of virology ·Vol. 63 ·No. 6 ·1989-06-00 ·Pages 2534-42

Bradley G, Hayashi M, Lancz G, Tanaka A, Nonoyama M

Abstract

The BamHI H fragment of Marek's disease virus (MDV), which has been hypothesized to contain a tumor-inducing gene, was partially sequenced and analyzed for transcriptional activity. Transcription of several RNAs was found to initiate within BamHI-H, with the major transcripts initiating on either side of a putative MDV origin of lytic replication. A 1.8-kilobase gene family found to be produced only by pathogenic MDV was detected, and its transcription map was produced. It is hypothesized that the 1.8-kilobase gene family is directly associated with the tumorigenic potential of MDV.

MeSH Terms
Animals Base Sequence Blotting, Northern Blotting, Southern Cells, Cultured Chick Embryo DNA, Viral/genetics Deoxyribonuclease BamHI Endonucleases Exons Fibroblasts Gene Amplification Genes, Viral Herpesvirus 2, Gallid/genetics Molecular Sequence Data Nucleic Acid Hybridization RNA, Viral/genetics Restriction Mapping Single-Strand Specific DNA and RNA Endonucleases Specific Pathogen-Free Organisms Transcription, Genetic
Chemicals
DNA, Viral RNA, Viral Endonucleases Deoxyribonuclease BamHI Single-Strand Specific DNA and RNA Endonucleases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bradley G
Department of Medical Microbiology, School of Medicine, University of South Florida, Tampa 33612.
Hayashi M
Lancz G
Tanaka A
Nonoyama M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.63.6.2534-2542.1989
Published
1989-06-00
Pages
2534-42
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250719
Subset
IM
Grants
NCI NIH HHS · R01 CA-31949 · United States
NCI NIH HHS · R01 CA-31950 · United States
NCI NIH HHS · R01 CA-36895 · United States
Databases
GENBANK
M26392
External Links
PubMed source DOI: 10.1128/JVI.63.6.2534-2542.1989 PMC Full Text View journal details
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