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PMID: 2538830 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two sodium-channel genes in Drosophila: implications for channel diversity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 6 ·1989-03-00 ·Pages 2079-82

Ramaswami M, Tanouye MA

Abstract

We describe two Drosophila melanogaster transcription units that are highly homologous to a rat Na+-channel cDNA. They appear to encode the major subunits of two distinct Na+-channel proteins. One of these maps to the second chromosome and is identical to a Na+-channel gene whose partial sequence has been previously reported [Salkoff, L., Butler, A., Wei, A., Scavarda, N., Giffen, K., Ifune, K., Goodman, R. & Mandel, G. (1987) Science 237, 744-749]. The other transcription unit maps to position 14C/D, on the X chromosome, close to the paralyzed (para) gene. Mutations in para affect membrane excitability in Drosophila neurons [Ganetzky, B. & Wu, C.F. (1986) Annu. Rev. Genet. 20, 13-44]. Sequence comparisons suggest that two Na+-channel genes arose early in evolution, before the divergence of vertebrate and invertebrate lines.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Chromosome Mapping DNA/genetics DNA Probes Drosophila melanogaster/genetics Genetic Variation Molecular Sequence Data Mutation Nucleic Acid Hybridization Rats Sequence Homology, Nucleic Acid Sodium Channels/physiology
Chemicals
DNA Probes Sodium Channels DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ramaswami M
Division of Biology, California Institute of Technology, Pasadena 91125.
Tanouye M A
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.6.2079
Published
1989-03-00
Pages
2079-82
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286851
Subset
IM
Grants
NINDS NIH HHS · NS21327-01 · United States
Databases
GENBANK
J04508
External Links
PubMed source DOI: 10.1073/pnas.86.6.2079 PMC Full Text View journal details
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