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PMID: 2525482 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Interferon receptors and their role in interferon action.

Experientia ·Vol. 45 ·No. 6 ·1989-06-15 ·Pages 508-13

Grossberg SE, Taylor JL, Kushnaryov VM

Abstract

Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.

MeSH Terms
Animals Cloning, Molecular Humans Interferon Type I/metabolism Interferon-gamma/metabolism Models, Biological Receptors, Immunologic/classification,isolation & purification,physiology Receptors, Interferon
Chemicals
Interferon Type I Receptors, Immunologic Receptors, Interferon Interferon-gamma
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Grossberg S E
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226.
Taylor J L
Kushnaryov V M
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40 references, click to expand
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01990499
Published
1989-06-15
Pages
508-13
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NEI NIH HHS · R 01-EY 06990 · United States
External Links
PubMed source DOI: 10.1007/BF01990499
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