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PMID: 3745987 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Internalization and transport of mouse beta-interferon into the cell nucleus.

Journal of interferon research ·Vol. 6 ·No. 3 ·1986-06-00 ·Pages 241-5

Kushnaryov VM, MacDonald HS, Debruin J, Lemense GP, Sedmak JJ, Grossberg SE

Abstract

An electron microscopic technique employing postembedding immunolabeling was used to identify unmodified, intracellular MuIFN-beta molecules. The MuIFN-beta was rapidly internalized by receptor-dependent endocytosis and within three minutes a majority of internalized MuIFN-beta molecules was detected within the cell nucleus.

MeSH Terms

Animals Biological Transport, Active Cell Nucleus/metabolism Endocytosis Interferon Type I/metabolism L Cells/metabolism,ultrastructure Mice

Chemicals

Interferon Type I

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kushnaryov V M

MacDonald H S

Debruin J

Lemense G P

Sedmak J J

Grossberg S E

Article Info

Journal

Journal of interferon research

Abbr.

J Interferon Res

ISSN

0197-8357

DOI

10.1089/jir.1986.6.241

Published

1986-06-00

Pages

241-5

Language

English

Region

United States

NLM ID

8100396

Subset

Grants

NCRR NIH HHS · 5-FO7-RR05434 · United States

External Links

PubMed source DOI: 10.1089/jir.1986.6.241

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Internalization and transport of mouse beta-interferon into the cell nucleus.

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