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PMID: 2523687 Published · ppublish English Journal Article

Transferable vancomycin and teicoplanin resistance in Enterococcus faecium.

Antimicrobial agents and chemotherapy ·Vol. 33 ·No. 1 ·1989-01-00 ·Pages 10-5

Leclercq R, Derlot E, Weber M, Duval J, Courvalin P

Abstract

Enterococcus faecium BM4165 and BM4178, isolated from immunocompromised patients, one treated with vancomycin, were inducibly resistant to high levels of the glycopeptide antibiotics vancomycin and teicoplanin but susceptible to the new lipopeptide daptomycin (LY146032). Strain BM4165 was also resistant to macrolidelincosamide-streptogramin B-type (MLS) antibiotics. The genes conferring resistance to glycopeptides and to MLS antibiotics in strain BM4165 were carried on plasmids pIP819 and pIP821, respectively; pIP819 also carried genes that encoded resistance to MLS antibiotics. The two plasmids, which were distinct although related, were self-transferable to other E. faecium strains. Plasmid pIP819 could also conjugate to E. faecalis, Streptococcus sanguis, S. pyogenes, S. lactis, and Listeria monocytogenes, in which it conferred inducible glycopeptide resistance, but not to S. aureus. Glycopeptide-inactivating activity was not detected, and the biochemical mechanism of resistance remains unknown. Based on this first report of transferable resistance to glycopeptides, we anticipate dissemination of resistance to these antibiotics in gram-positive cocci and bacilli in which it can be phenotypically expressed.

MeSH Terms
Adult Anti-Bacterial Agents/pharmacology Bacillus subtilis/drug effects,genetics Child Deoxyribonuclease EcoRI Deoxyribonuclease HindIII Drug Resistance, Microbial/genetics Glycopeptides/pharmacology Humans Listeria monocytogenes/drug effects,genetics Plasmids Staphylococcus aureus/drug effects,genetics Streptococcus/drug effects,genetics Teicoplanin Vancomycin/pharmacology
Chemicals
Anti-Bacterial Agents Glycopeptides Teicoplanin Vancomycin Deoxyribonuclease EcoRI Deoxyribonuclease HindIII
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Leclercq R
Service de Bactériologie-Virologie-Hygiène, Hôpital Henri Mondor, Université Paris XII, Créil, France.
Derlot E
Weber M
Duval J
Courvalin P
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.33.1.10
Published
1989-01-00
Pages
10-5
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC171412
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.33.1.10 PMC Full Text View journal details
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