Home LiteratureArticle Details
PMID: 2501666 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

c-fos proto-oncogene expression in the nervous system during mouse development.

Molecular and cellular biology ·Vol. 9 ·No. 5 ·1989-05-00 ·Pages 2269-72

Caubet JF

Abstract

I show, by in situ hybridization, that c-fos is expressed in the nervous system during mouse development. This expression was found to be restricted to specific regions at late stages of development (day 16 postcoitum), particularly to the spinal cord, dorsal root ganglia, and olfactory lobe. The c-fos protein may play a role in the maturation of these structures by activating specific genes.

MeSH Terms
Animals Gene Expression Regulation Mice Nervous System/embryology Nucleic Acid Hybridization Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-myc Proto-Oncogenes RNA Probes RNA, Messenger/genetics,metabolism Tissue Distribution
Chemicals
Proto-Oncogene Proteins Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-myc RNA Probes RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Caubet J F
Institut National de la Santé et de la Recherche Médicale U 139, Hôpital Henri Mondor, Créteil, France.
References (33)
33 references, click to expand
  1. Nucleotide sequence comparison of normal and translocated murine c-myc genes.
    Nature. 1984 Aug 2-8;310(5976):423-5 PMID: 6462227
  2. Enhanced expression of TGF-beta and c-fos mRNAs in the growth plates of developing human long bones.
    Development. 1988 Mar;102(3):461-70 PMID: 3141126
  3. Induction of c-fos gene and protein by growth factors precedes activation of c-myc.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):716-20 PMID: 6334806
  4. Molecular probes for the development and plasticity of neural crest derivatives.
    Cell. 1985 Sep;42(2):649-62 PMID: 3839717
  5. Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines.
    Science. 1985 Sep 20;229(4719):1265-8 PMID: 4035354
  6. Induction of the proto-oncogene fos by nerve growth factor.
    Proc Natl Acad Sci U S A. 1985 Nov;82(21):7330-4 PMID: 2997786
  7. Control elements of the Drosophila segmentation gene fushi tarazu.
    Cell. 1985 Dec;43(3 Pt 2):603-13 PMID: 3935327
  8. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
    Nature. 1985 Dec 19-1986 Jan 1;318(6047):630-5 PMID: 4079979
  9. Regulation of c-fos transcription in mouse fibroblasts: identification of DNase I-hypersensitive sites and regulatory upstream sequences.
    EMBO J. 1985 Dec 30;4(13B):3711-6 PMID: 3004967
  10. Alpha-thalassemia due to the deletion of nucleotides -2 and -3 preceding the AUG initiation codon affects translation efficiency both in vitro and in vivo.
    Nucleic Acids Res. 1986 Apr 25;14(8):3279-92 PMID: 3703675
  11. The long and the short of long-term memory--a molecular framework.
    Nature. 1986 Jul 31-Aug 6;322(6078):419-22 PMID: 2874497
  12. Role of ion flux in the control of c-fos expression.
    Nature. 1986 Aug 7-13;322(6079):552-5 PMID: 2426600
  13. Stimulation of neuronal acetylcholine receptors induces rapid gene transcription.
    Science. 1986 Oct 3;234(4772):80-3 PMID: 3749894
  14. The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose.
    Science. 1986 Dec 12;234(4782):1417-9 PMID: 3491427
  15. Chromatin association and DNA binding properties of the c-fos proto-oncogene product.
    Nucleic Acids Res. 1987 Jan 12;15(1):277-92 PMID: 3103098
  16. Presence of c-fos-like immunoreactivity in the adult rat brain.
    Eur J Pharmacol. 1987 Mar 3;135(1):113-4 PMID: 3106073
  17. Mapping patterns of c-fos expression in the central nervous system after seizure.
    Science. 1987 Jul 10;237(4811):192-7 PMID: 3037702
  18. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation.
    Nature. 1987 Aug 13-19;328(6131):632-4 PMID: 3112583
  19. Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissue.
    Nature. 1987 Aug 20-26;328(6132):711-4 PMID: 3614378
  20. Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus.
    Nature. 1987 Oct 1-7;329(6138):441-2 PMID: 3116433
  21. The fos oncogene.
    Adv Cancer Res. 1987;49:29-52 PMID: 2823543
  22. Generalized seizures induce c-fos protein(s) in mammalian neurons.
    Neurosci Lett. 1987 Nov 23;82(2):157-61 PMID: 2447534
  23. The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites.
    Science. 1988 Mar 4;239(4844):1150-3 PMID: 2964084
  24. Ontogeny of the calcium binding protein calbindin D-28k in the rat nervous system.
    Anat Embryol (Berl). 1987;177(1):15-28 PMID: 3439634
  25. Common DNA binding site for Fos protein complexes and transcription factor AP-1.
    Cell. 1988 Feb 12;52(3):471-80 PMID: 3125983
  26. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.
    Cell. 1988 Apr 8;53(1):37-43 PMID: 3127059
  27. Localization and induction of c-fos protein-like immunoreactive material in the nuclei of adult mammalian neurons.
    Brain Res. 1988 Feb 9;440(2):252-60 PMID: 3129127
  28. The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin.
    Differentiation. 1987;36(2):130-7 PMID: 2452109
  29. Fos-associated protein p39 is the product of the jun proto-oncogene.
    Science. 1988 May 20;240(4855):1010-6 PMID: 3130660
  30. Expression of c-fos protein in brain: metabolic mapping at the cellular level.
    Science. 1988 Jun 3;240(4857):1328-31 PMID: 3131879
  31. Detection of fos protein during osteogenesis by monoclonal antibodies.
    Mol Cell Biol. 1988 May;8(5):2251-6 PMID: 3133556
  32. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons.
    EMBO J. 1988 May;7(5):1345-53 PMID: 3409867
  33. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.
    Nature. 1984 Oct 4-10;311(5985):433-8 PMID: 6090941
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.5.2269-2272.1989
Published
1989-05-00
Pages
2269-72
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363028
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.9.5.2269-2272.1989 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2