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PMID: 2463636 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 2 ·1989-01-00 ·Pages 656-60

Boehm KD, Kelley MF, Ilan J, Ilan J

Abstract

The lymphokine interleukin 2 is an important immune system regulatory glycopolypeptide. It is produced by antigen- or mitogen-stimulated T lymphocytes and is required for the proliferation or clonal expansion of activated T lymphocytes. In this report, it is demonstrated by RNA transfer blot hybridization that the poly(A)+ RNA population of the human placenta contains a 0.85-kilobase RNA transcript that specifically hybridizes to a human interleukin 2 cDNA probe. By using hybridization histochemistry in situ, it is further shown that interleukin 2 RNA transcripts are localized, primarily, to the syncytial (syncytiotrophoblast) layer of the human placenta. Possible roles for syncytiotrophoblast-produced interleukin 2 are suggested and discussed.

MeSH Terms
Autoradiography DNA Probes Electrophoresis, Agar Gel Female Gene Expression Regulation Histocytochemistry Humans Interleukin-2/genetics Nucleic Acid Hybridization Poly A/analysis Pregnancy RNA/analysis RNA, Messenger Trophoblasts/analysis
Chemicals
DNA Probes Interleukin-2 RNA, Messenger Poly A RNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Boehm K D
Department of Reproductive Biology, Case Western Reserve, University School of Medicine, OH.
Kelley M F
Ilan J
Ilan J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.2.656
Published
1989-01-00
Pages
656-60
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286532
Subset
IM
Grants
NCI NIH HHS · CA-43703 · United States
NICHD NIH HHS · HD-18271 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.2.656 PMC Full Text View journal details
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