Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

Nature ·Vol. 316 ·No. 6030 ·1985-00-00 ·Pages 701-5

Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV

Abstract

The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.

MeSH Terms

Amino Acid Sequence Base Sequence DNA/analysis Humans Neoplasms/analysis Peptides/genetics RNA, Messenger/analysis Transforming Growth Factors

Chemicals

Peptides RNA, Messenger Transforming Growth Factors DNA

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Derynck R

Jarrett J A

Chen E Y

Eaton D H

Bell J R

Assoian R K

Roberts A B

Sporn M B

Goeddel D V

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/316701a0

Published

1985-00-00

Pages

701-5

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X02812

External Links

PubMed source DOI: 10.1038/316701a0 View journal details

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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

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