9-Amino-1,2,3,4-tetrahydroacridine (THA) is a potent blocker of cardiac potassium channels.

British journal of pharmacology ·Vol. 92 ·No. 3 ·1987-11-00 ·Pages 521-5

Osterrieder W

Abstract

1. 9-Amino-1,2,3,4-tetrahydroacridine (THA) is a compound with structural similarity to the K+ channel blocker 4-aminopyridine. It was investigated for its effects on myocardial membrane currents in guinea-pig isolated ventricular myocytes. 2. THA prolonged the transmembrane action potential and decreased the amplitude of its plateau in a reversible manner. 3. Voltage-clamp experiments showed that THA reduced the inwardly rectifying and the time-dependent outward K+ currents as well as the slow inward Ca2+ current. 4. The degree of block of the inwardly rectifying K+ current depended on the membrane potential, being more pronounced at more positive potentials.

MeSH Terms

Action Potentials/drug effects Aminoacridines/pharmacology Animals Female Guinea Pigs Heart/drug effects In Vitro Techniques Ion Channels/drug effects Male Membrane Potentials/drug effects Myocardium/metabolism Potassium/metabolism Tacrine/pharmacology

Chemicals

Aminoacridines Ion Channels Tacrine Potassium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Osterrieder W

Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Ltd, Basel, Switzerland.

References (14)

14 references, click to expand

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Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1987.tb11352.x

Published

1987-11-00

Pages

521-5

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1853671

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1987.tb11352.x PMC Full Text View journal details

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9-Amino-1,2,3,4-tetrahydroacridine (THA) is a potent blocker of cardiac potassium channels.

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