Home LiteratureArticle Details
PMID: 667299 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

3,4-diaminopyridine. A potent new potassium channel blocker.

Biophysical journal ·Vol. 22 ·No. 3 ·1978-06-00 ·Pages 507-12

Kirsch GE, Narahashi T

Abstract

3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes. The apparent dissociation constants for this action are estimated to be 5.8 micron and 0.7 micron for external and internal applications, respectively, the potency being about 50 times higher than that of 4-aminopyridine. The block depends upon the membrane potential, time, and stimulus frequency. 3,4-diaminopyridine shows great promise as a useful tool for the study of membrane ionic channels.

MeSH Terms
Action Potentials/drug effects Animals Axons/drug effects,metabolism Decapodiformes Membrane Potentials/drug effects Membranes/drug effects,metabolism Potassium/metabolism Pyridines/pharmacology
Chemicals
Pyridines Potassium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kirsch G E
Narahashi T
References (9)
9 references, click to expand
  1. ANOMALOUS RECTIFICATION IN THE SQUID GIANT AXON INJECTED WITH TETRAETHYLAMMONIUM CHLORIDE.
    J Gen Physiol. 1965 May;48:859-72 PMID: 14324992
  2. The effect of internal and external 4-aminopyridine on the potassium currents in intracellularly perfused squid giant axons.
    J Physiol. 1977 Jun;268(2):511-32 PMID: 874919
  3. The facilitatory actions of aminopyridines and tetraethylammonium on neuromuscular transmission and muscle contractility in avian muscle.
    Naunyn Schmiedebergs Arch Pharmacol. 1977 Aug;299(1):53-60 PMID: 20582
  4. Dynamics of aminopyridine block of potassium channels in squid axon membrane.
    J Gen Physiol. 1976 Nov;68(5):519-35 PMID: 993770
  5. The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds.
    J Pharmacol Exp Ther. 1970 Jan;171(1):32-44 PMID: 5410936
  6. Chemicals as tools in the study of excitable membranes.
    Physiol Rev. 1974 Oct;54(4):813-89 PMID: 4153804
  7. The potentiating effects of 4-aminopyridine on adrenergic transmission in the rabbit vas deferens.
    Eur J Pharmacol. 1976 Jul;38(1):71-8 PMID: 182508
  8. Interactions of aminopyridines with potassium channels of squid axon membranes.
    Biophys J. 1976 Jan;16(1):77-81 PMID: 1244890
  9. Mechanism of action of propranolol on squid axon membranes.
    J Pharmacol Exp Ther. 1973 Jan;184(1):155-62 PMID: 4686004
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(78)85503-9
Published
1978-06-00
Pages
507-12
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1473482
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(78)85503-9 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2