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PMID: 24429633 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The multilayered complexity of ceRNA crosstalk and competition.

Nature ·Vol. 505 ·No. 7483 ·2014-01-16 ·Pages 344-52

Tay Y, Rinn J, Pandolfi PP

Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

MeSH Terms
Animals Argonaute Proteins/metabolism Binding, Competitive Humans MicroRNAs/genetics,metabolism Pseudogenes/genetics RNA/genetics,metabolism RNA Editing RNA, Circular RNA, Long Noncoding/genetics,metabolism RNA, Messenger/genetics,metabolism RNA-Binding Proteins/metabolism
Chemicals
Argonaute Proteins MicroRNAs RNA, Circular RNA, Long Noncoding RNA, Messenger RNA-Binding Proteins RNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tay Yvonne
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Rinn John
1] Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA. [3] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.
Pandolfi Pier Paolo
Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature12986
Published
2014-01-16
Pages
344-52
Language
English
Region
England
NLM ID
0410462
PMCID
PMC4113481
Subset
IM
Grants
NCI NIH HHS · R01 CA082328 · United States
NCI NIH HHS · R01 CA170158 · United States
NCI NIH HHS · R01 CA-82328 · United States
External Links
PubMed source DOI: 10.1038/nature12986 PMC Full Text View journal details
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