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PMID: 2434836 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.

Molecular and cellular biology ·Vol. 7 ·No. 2 ·1987-02-00 ·Pages 946-50

Azarnia R, Loewenstein WR

Abstract

We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.

MeSH Terms
Animals Antigens, Viral, Tumor/physiology Cell Communication Cells, Cultured Intercellular Junctions/physiology Mutation Polyomavirus/physiology Protein-Tyrosine Kinases/physiology Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins pp60(c-src) Rats Temperature
Chemicals
Antigens, Viral, Tumor Proto-Oncogene Proteins Protein-Tyrosine Kinases Proto-Oncogene Proteins pp60(c-src)
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Azarnia R
Loewenstein W R
References (36)
36 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.2.946-950.1987
Published
1987-02-00
Pages
946-50
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC365156
Subset
IM
Grants
NCI NIH HHS · CA14464 · United States
External Links
PubMed source DOI: 10.1128/mcb.7.2.946-950.1987 PMC Full Text View journal details
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