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PMID: 2422116 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Viral sequences are associated with many histocompatibility genes.

Immunogenetics ·Vol. 23 ·No. 4 ·1986-00-00 ·Pages 233-45

Rossomando A, Meruelo D

Abstract

A C57BL/6By 5.5 kb Pvu II polymorphic restriction fragment which hybridizes with a spleen focus-forming env probe and maps in the H-30 region has been cloned, and a 358 bp subfragment subcloned. Hybridization and sequencing studies show that the 358 bp fragment is encoded by the region of the pol gene of murine retrovirus which codes for an endonuclease critical for viral integration. Hybridizations of digested murine genomic DNAs with the 358 bp probe generate 31 restriction fragment length polymorphisms (RFLPs); 16 of these can be placed near the following 15 minor histocompatability (H) loci: H-3, H-4, H-7, H-13, H-15, H-16, H-17, H-19, H-22, H-24, H-27, H-30, H-34, H-36, and H-38. We suggest that the proximity of viral sequences to H loci is probably evolutionarily and functionally significant and that the closeness of viral sequences and minor H loci can probably be utilized to facilitate the cloning of minor H genes. During the course of these studies, it has become possible to tentatively assign H-17, H-34, and H-38 to chromosome 12. In addition, it was observed that several H-2 congenic strains retain portions of chromosome 12 from the parental donor strains used in their derivation.

MeSH Terms
Animals Base Sequence Biological Evolution Centromere Chromosome Mapping Cloning, Molecular DNA Restriction Enzymes Endonucleases/genetics Genes, Viral Genetic Linkage Histocompatibility Antigens/genetics Mice Minor Histocompatibility Loci Nucleic Acid Hybridization Polymorphism, Genetic RNA-Directed DNA Polymerase/genetics Sequence Homology, Nucleic Acid
Chemicals
Histocompatibility Antigens RNA-Directed DNA Polymerase Endonucleases DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rossomando A
Meruelo D
References (41)
41 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00373018
Published
1986-00-00
Pages
233-45
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NCI NIH HHS · CA22247 · United States
NCI NIH HHS · CA31346 · United States
NCI NIH HHS · CA35482 · United States
Databases
GENBANK
M15369
External Links
PubMed source DOI: 10.1007/BF00373018 View journal details
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