Abstract
A growth factor that is mitogenic for vascular endothelial cells, with an ED50 of approximately 1 ng/ml, has been purified 170,000-fold to apparent homogeneity from tissue culture medium conditioned by a rat glioma-derived cell line. The pure protein is a 46-kDa dimer composed of two subunits of equivalent mass as established by comparison of migration in SDS/polyacrylamide gels with and without prior reduction. This glioma-derived growth factor is a glycoprotein and is not mitogenic for BALB/c 3T3 fibroblasts, properties that further distinguish it from other well-characterized vascular endothelial cell mitogens. In contrast to acidic and basic fibroblast growth factors and to platelet-derived endothelial cell growth factor, which have no secretory leader sequences and might only be released by leakage from damaged cells, the glycoprotein nature of this mitogen implies that it is processed through the glycosylating secretory pathway. This secretable growth factor could, therefore, be readily available in the extracellular space under normal physiological conditions in vivo to promote vascular endothelial cell proliferation associated with blood-vessel growth and maintenance.
MeSH Terms
Amino Acids/analysis
Animals
Cell Line
Cells, Cultured
Chromatography, Affinity
Chromatography, Gel
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Electrophoresis, Polyacrylamide Gel
Endothelial Growth Factors
Endothelium, Vascular/cytology,drug effects
Glioma
Glycoproteins/isolation & purification,pharmacology
Growth Substances/isolation & purification,pharmacology
Humans
Mice
Mice, Inbred BALB C
Molecular Weight
Rats
Umbilical Veins
Chemicals
Amino Acids
Endothelial Growth Factors
Glycoproteins
Growth Substances
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Conn G
Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065.
Soderman D D
Schaeffer M T
Wile M
Hatcher V B
Thomas K A
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