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PMID: 2413439 Published · ppublish English Journal Article

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 19 ·1985-10-00 ·Pages 6409-13

Thomas KA, Rios-Candelore M, Giménez-Gallego G, DiSalvo J, Bennett C, Rodkey J, Fitzpatrick S

Abstract

Pure bovine brain-derived acidic fibroblast growth factor is a very potent mitogen for vascular endothelial cells in culture and, in the presence of heparin, induces blood vessel growth in vivo. Partial amino acid sequence determinations confirm that this mitogen is a unique protein having amino acid sequence homology with human interleukin 1.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Brain Chemistry Cattle Cells, Cultured Chick Embryo/drug effects Endothelium/drug effects Fibroblast Growth Factors/genetics Interleukin-1/genetics Neovascularization, Pathologic Sequence Homology, Nucleic Acid
Chemicals
Interleukin-1 Fibroblast Growth Factors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Thomas K A
Rios-Candelore M
Giménez-Gallego G
DiSalvo J
Bennett C
Rodkey J
Fitzpatrick S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.19.6409
Published
1985-10-00
Pages
6409-13
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC390725
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.82.19.6409 PMC Full Text View journal details
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