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PMID: 24058764 Published · ppublish English Journal Article Review

The spectrum of STAT functions in mammary gland development.

JAK-STAT ·Vol. 1 ·No. 3 ·2012-07-01 ·Pages 151-8

Hughes K, Watson CJ

Abstract

The signal transducer and activator of transcription (STAT) family of transcription factors have a spectrum of functions in mammary gland development. In some cases these roles parallel those of STATs in other organ systems, while in other instances the function of individual STATs in the mammary gland is specific to this tissue. In the immune system, STAT6 is associated with differentiation of T helper cells, while in the mammary gland, it has a fundamental role in the commitment of luminal epithelial cells to the alveolar lineage. STAT5A is required for the production of luminal progenitor cells from mammary stem cells and is essential for the differentiation of milk producing alveolar cells during pregnancy. By contrast, the initiation of regression following weaning heralds a dramatic and specific activation of STAT3, reflecting its pivotal role in the regulation of cell death and tissue remodeling during mammary involution. Although it has been demonstrated that STAT1 is regulated during a mammary developmental cycle, it is not yet determined whether it has a specific, non-redundant function. Thus, the mammary gland constitutes an unusual example of an adult organ in which different STATs are sequentially activated to orchestrate the processes of functional differentiation, cell death and tissue remodeling.

Keywords
STAT apoptosis differentiation gene targeting mammary gland microarray mouse
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hughes Katherine
Department of Pathology; University of Cambridge; Cambridge, UK.
Watson Christine J
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Article Info
Journal
JAK-STAT
Abbr.
JAKSTAT
ISSN
2162-3988
DOI
10.4161/jkst.19691
Published
2012-07-01
Pages
151-8
Language
English
Region
United States
NLM ID
101591376
PMCID
PMC3670238
Grants
Medical Research Council · G0900980 · United Kingdom
External Links
PubMed source DOI: 10.4161/jkst.19691 PMC Full Text
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