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PMID: 21436836 Published · ppublish English Journal Article Review

Genomic views of STAT function in CD4+ T helper cell differentiation.

Nature reviews. Immunology ·Vol. 11 ·No. 4 ·2011-04-00 ·Pages 239-50

O'Shea JJ, Lahesmaa R, Vahedi G, Laurence A, Kanno Y

Abstract

Signal transducer and activator of transcription (STAT) proteins are well known for their essential roles in transmitting cytokine-mediated signals and specifying T helper (T(H)) cell differentiation. Recent technological advances have revealed that STAT proteins have broad and complex roles in gene regulation and epigenetic control, including important roles as functional repressors. However, the challenge of how to link signal transduction, nucleosome biology and gene regulation remains. The relevance of tackling this problem is highlighted by genome-wide association studies that link cytokine signalling and STATs to various autoimmune or immune deficiency disorders. Defining exactly how extrinsic signals control the specification and plasticity of T(H) cells will provide important insights and perhaps therapeutic opportunities in these diseases.

MeSH Terms
Animals Autoimmune Diseases/genetics Cytokines/immunology Gene Expression Regulation/immunology Genome-Wide Association Study Genomics/methods Humans Immunologic Deficiency Syndromes/genetics,immunology Lymphocyte Activation/genetics,immunology Mice Nucleosomes/genetics,immunology STAT Transcription Factors/genetics,immunology Sequence Analysis, DNA Signal Transduction/genetics,immunology T-Lymphocytes, Helper-Inducer/immunology
Chemicals
Cytokines Nucleosomes STAT Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
O'Shea John J
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. osheajo@mail.nih.gov
Lahesmaa Riitta
Vahedi Golnaz
Laurence Arian
Kanno Yuka
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2958
Email
osheajo@mail.nih.gov
Published
2011-04-00
Pages
239-50
Language
English
Region
England
NLM ID
101124169
PMCID
PMC3070307
Subset
IM
External Links
PubMed source DOI: 10.1038/nri2958 PMC Full Text View journal details
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