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PMID: 24043949 Published · epublish English Journal Article Review

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition.

OncoTargets and therapy ·Vol. 6 ·2013-09-06 ·Pages 1249-59

Espinoza I, Pochampally R, Xing F, Watabe K, Miele L

Abstract

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.

Keywords
EMT Notch inhibitors Notch signaling cancer stem cells mesenchymal stem cells metastases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Espinoza Ingrid
Cancer Institute, University of Mississippi Medical Center, Jackson, MS, USA ; Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS, USA.
Pochampally Radhika
Xing Fei
Watabe Kounosuke
Miele Lucio
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Article Info
Journal
OncoTargets and therapy
Abbr.
Onco Targets Ther
ISSN
1178-6930
DOI
10.2147/OTT.S36162
Published
2013-09-06
Epub
2013-00-06
Pages
1249-59
Language
English
Region
New Zealand
NLM ID
101514322
PMCID
PMC3772757
Grants
NCI NIH HHS · R01 CA124650 · United States
NCI NIH HHS · R01 CA129000 · United States
NCI NIH HHS · R01 CA151851 · United States
External Links
PubMed source DOI: 10.2147/OTT.S36162 PMC Full Text View journal details
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