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PMID: 20449641 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Epithelial-to-mesenchymal transitions and circulating tumor cells.

Journal of mammary gland biology and neoplasia ·Vol. 15 ·No. 2 ·2010-06-00 ·Pages 261-73

Bonnomet A, Brysse A, Tachsidis A, Waltham M, Thompson EW, Polette M, Gilles C

Abstract

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival.

MeSH Terms
Animals Breast Neoplasms/pathology,physiopathology Cell Dedifferentiation Cell Transdifferentiation Epithelial Cells/physiology Female Humans Mammary Neoplasms, Experimental/pathology,physiopathology Mesenchymal Stem Cells/physiology Neoplasm Invasiveness Neoplasm Metastasis Neoplastic Cells, Circulating Phenotype
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Bonnomet Arnaud
Laboratory of Tumor and Developmental Biology, Liège University, GIGA - Cancer, C.H.U. Sart-Tilman, Tour de Pathologie B23, 4000 Liège, Belgium.
Brysse Anne
Tachsidis Anthony
Waltham Mark
Thompson Erik W
Polette Myriam
Gilles Christine
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1573-7039
DOI
10.1007/s10911-010-9174-0
Published
2010-06-00
Epub
2010-00-07
Pages
261-73
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1007/s10911-010-9174-0 View journal details
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