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PMID: 20022691 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cross-talk between miRNA and Notch signaling pathways in tumor development and progression.

Cancer letters ·Vol. 292 ·No. 2 ·2010-06-28 ·Pages 141-8

Wang Z, Li Y, Kong D, Ahmad A, Banerjee S, Sarkar FH

Abstract

Notch signaling pathways are known to regulate many cellular processes, including cell proliferation, apoptosis, migration, invasion, and angiogenesis, and is one of the most important signaling pathway during normal development. Recently, emerging evidences suggest that microRNAs (miRNAs) can function as key regulators of various biological and pathologic processes during tumor development and progression. Notch signaling has also been reported to be regulated through cross-talk with many pathways and factors where miRNAs appears to play a major role. This article will provide a brief overview of the published evidences for the cross-talks between Notch and miRNAs. Further, we summarize how targeting miRNAs by natural agents could become a novel and safer approach for the prevention of tumor progression and treatment.

MeSH Terms
Disease Progression Humans MicroRNAs/metabolism Receptors, Notch/metabolism Signal Transduction
Chemicals
MicroRNAs Receptors, Notch
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wang Zhiwei
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States.
Li Yiwei
Kong Dejuan
Ahmad Aamir
Banerjee Sanjeev
Sarkar Fazlul H
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Article Info
Journal
Cancer letters
Abbr.
Cancer Lett
ISSN
1872-7980
DOI
10.1016/j.canlet.2009.11.012
Published
2010-06-28
Epub
2009-00-22
Pages
141-8
Language
English
Region
Ireland
NLM ID
7600053
PMCID
PMC2857527
Subset
IM
Grants
NCI NIH HHS · 1R01CA101870 · United States
NCI NIH HHS · R01 CA108535-04 · United States
NCI NIH HHS · R01 CA131151 · United States
NCI NIH HHS · 5R01CA131151 · United States
NCI NIH HHS · R01 CA101870-05 · United States
NCI NIH HHS · 5P20-CA101936 · United States
NCI NIH HHS · R01 CA131151-02S1 · United States
NCI NIH HHS · 1R01CA132794 · United States
NCI NIH HHS · R01 CA083695-07 · United States
NCI NIH HHS · 5R01CA083695 · United States
NCI NIH HHS · R01 CA101870 · United States
NCI NIH HHS · R01 CA131151-02 · United States
NCI NIH HHS · R01 CA132794-01A1 · United States
NCI NIH HHS · P20 CA101936 · United States
NCI NIH HHS · R01 CA108535 · United States
NCI NIH HHS · R01 CA132794 · United States
NCI NIH HHS · R01 CA083695 · United States
External Links
PubMed source DOI: 10.1016/j.canlet.2009.11.012 PMC Full Text View journal details
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