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PMID: 23842645 Published · ppublish English Research Support, N.I.H., Extramural Review

The DREAM complex: master coordinator of cell cycle-dependent gene expression.

Nature reviews. Cancer ·Vol. 13 ·No. 8 ·2013-00-00 ·Pages 585-95

Sadasivam S, DeCaprio JA

Abstract

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.

MeSH Terms
Cell Cycle/genetics Cell Cycle Proteins/physiology Cell Proliferation Cell Transformation, Neoplastic/genetics Gene Expression Regulation/physiology Humans Retinoblastoma Protein/physiology Transcription Factors/physiology
Chemicals
Cell Cycle Proteins Retinoblastoma Protein Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sadasivam Subhashini
Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560065, India.
DeCaprio James A
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3556
Published
2013-00-00
Epub
2013-00-11
Pages
585-95
Language
English
Region
England
NLM ID
101124168
PMCID
PMC3986830
Subset
IM
Grants
NCI NIH HHS · P01CA050661 · United States
NCI NIH HHS · R01CA63113 · United States
NCI NIH HHS · P01 CA050661 · United States
NCI NIH HHS · R01 CA063113 · United States
NCI NIH HHS · R01 CA173023 · United States
Corrections
ErratumIn
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External Links
PubMed source DOI: 10.1038/nrc3556 PMC Full Text View journal details
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