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PMID: 23788621 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A double take on bivalent promoters.

Genes & development ·Vol. 27 ·No. 12 ·2013-06-15 ·Pages 1318-38

Voigt P, Tee WW, Reinberg D

Abstract

Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark and the repressive H3K27me3 mark. These bivalent domains are considered to poise expression of developmental genes, allowing timely activation while maintaining repression in the absence of differentiation signals. Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remains controversial, not least because suitable genetic models to probe their function in developing organisms are missing. Here, we explore avenues to and from bivalency and propose that bivalent domains and associated chromatin-modifying complexes safeguard proper and robust differentiation.

Keywords
Polycomb Trithorax bivalent domains chromatin embryonic stem cells
MeSH Terms
Animals Cell Differentiation/genetics DNA Methylation/genetics Embryonic Stem Cells/cytology Gene Expression Regulation, Developmental Humans Promoter Regions, Genetic/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Voigt Philipp
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Tee Wee-Wei
Reinberg Danny
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.219626.113
Published
2013-06-15
Pages
1318-38
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC3701188
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM064844 · United States
NIGMS NIH HHS · R01 GM064844 · United States
NIGMS NIH HHS · R37GM037120 · United States
NIGMS NIH HHS · R37 GM037120 · United States
External Links
PubMed source DOI: 10.1101/gad.219626.113 PMC Full Text View journal details
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