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PMID: 23764050 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Structural determinants of arrestin functions.

Progress in molecular biology and translational science ·Vol. 118 ·2013-00-00 ·Pages 57-92

Gurevich VV, Gurevich EV

Abstract

Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elements, including regular microtubules and centrosomes. Here, we focus on the structural determinants that mediate various arrestin functions. The receptor-binding elements in arrestins were mapped fairly comprehensively, which set the stage for the construction of mutants targeting particular GPCRs. The elements engaged by other binding partners are only now being elucidated and in most cases we have more questions than answers. Interestingly, even very limited and imprecise identification of structural requirements for the interaction with very few other proteins has enabled the development of signaling-biased arrestin mutants. More comprehensive understanding of the structural underpinning of different arrestin functions will pave the way for the construction of arrestins that can link the receptor we want to the signaling pathway of our choosing.

MeSH Terms
Animals Arrestin/chemistry,metabolism Crystallography, X-Ray Humans Mutant Proteins/chemistry,metabolism Receptors, G-Protein-Coupled/metabolism Signal Transduction Structure-Activity Relationship
Chemicals
Arrestin Mutant Proteins Receptors, G-Protein-Coupled
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gurevich Vsevolod V
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
Gurevich Eugenia V
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Article Info
Journal
Progress in molecular biology and translational science
Abbr.
Prog Mol Biol Transl Sci
ISSN
1878-0814
DOI
10.1016/B978-0-12-394440-5.00003-6
Published
2013-00-00
Pages
57-92
Language
English
Region
Netherlands
NLM ID
101498165
PMCID
PMC4514030
Subset
IM
Grants
NIGMS NIH HHS · GM081756 · United States
NIDA NIH HHS · DA030103 · United States
NIGMS NIH HHS · R01 GM077561 · United States
NIGMS NIH HHS · R01 GM081756 · United States
NINDS NIH HHS · NS065868 · United States
NEI NIH HHS · EY011500 · United States
NINDS NIH HHS · R01 NS065868 · United States
NIGMS NIH HHS · GM077561 · United States
NIDA NIH HHS · R21 DA030103 · United States
NEI NIH HHS · R01 EY011500 · United States
NIDA NIH HHS · R13 DA037694 · United States
External Links
PubMed source DOI: 10.1016/B978-0-12-394440-5.00003-6 PMC Full Text
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