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PMID: 23538742 Published · ppublish English Journal Article

Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression.

Current pathobiology reports ·Vol. 1 ·No. 1 ·2013-03-01 ·Pages 19-28

Galvão RP, Zong H

Abstract

Inflammation has been closely linked to various forms of cancer. Less is known about the role of inflammation in glioma, especially at the initiation stage. In this review, we first describe the unique features of the immune system in the brain. We then discuss the current understanding of the mechanisms by which glioma cells modulate the immune system, especially how bi-directional communications between immune cells and glioma cells create an immunosuppressed microenvironment that promotes tumor survival and growth. We also address the potential tumor-initiating roles of inflammation in glioma. Finally, we describe several immunotherapy approaches currently being developed to reverse these interactions and stimulate the immune system to eliminate glioma cells.

Keywords
Glioma Immunosuppression Immunotherapy Inflammation Microglia T cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Galvão Rui Pedro
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Zong Hui
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Article Info
Journal
Current pathobiology reports
Abbr.
Curr Pathobiol Rep
ISSN
2167-485X
DOI
10.1007/s40139-012-0006-3
Published
2013-03-01
Pages
19-28
Language
English
Region
United States
NLM ID
101599032
PMCID
PMC3607461
Grants
NCI NIH HHS · R01 CA136495 · United States
External Links
PubMed source DOI: 10.1007/s40139-012-0006-3 PMC Full Text
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